Compound 28

Product Name: Compound 28
CAS No.: 1062172-60-4
Chemical Name: Compound 28
Synonyms: WYE-28;mTOR Inhibitor, WYE-28;Methyl 4-(6-(4-(3-(4-(hydroxymethyl)phenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate;4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylicacid,methylester;1-Piperidinecarboxylic acid, 4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester
CBNumber: CB84666318
Molecular Formula: C30H34N8O5
Formula Weight: 586.64
MOL File: 1062172-60-4.mol

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Compound 28 Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 60 mg/ml
form: White powder solid.
pka: 13.98±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21200
Product name: Compound 28
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21200
Product name: Compound 28
Packaging: 1mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 21200
Product name: Compound 28
Packaging: 5mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 21200
Product name: Compound 28
Packaging: 10mg
Price: $595
Updated: 2024/03/01

AK Scientific

Product number: 2206DC
Product name: Methyl4-[6-[4-[[4-(hydroxymethyl)phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
Packaging: 1mg
Price: $190
Updated: 2021/12/16

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Compound 28 Chemical Properties,Usage,Production

Uses

mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].

References

[1] Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. DOI:10.1021/jm900851f

Compound 28 Preparation Products And Raw materials

Raw materials

Preparation Products

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Compound 28 Suppliers

China 17 United States 3 Global 20

Nanjing Chemlin Chemical Co., Ltd

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Bide Pharmatech Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Shanghai Hongye Biotechnology Co. Ltd

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Shanghai Dongyang Biotechnology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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TargetMol Chemicals Inc.

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Nantong Hanfang Biotechnology Co. , Ltd.

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Tanmo Quality Inspection Technology Co., Ltd.

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Cayman Chemical Company

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Enzo Biochem Inc

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Foshan Minghua Biotechnology Co., Ltd.

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Neobioscience Co., Ltd.

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Absin Bioscience Inc.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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1062172-60-4, Compound 28Related Search:

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mTOR Inhibitor, WYE-28

WYE-28

1-Piperidinecarboxylic acid, 4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester

4-[6-[4-[[[[4-(hydroxymethyl)phenyl]amino]carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylicacid,methylester

Methyl 4-(6-(4-(3-(4-(hydroxymethyl)phenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

1062172-60-4