KU-55933

Product Name: KU-55933
CAS No.: 587871-26-9
Chemical Name: KU-55933
Synonyms: CS-63;U-55933;KV-55933;KU 55933 NEW;KU-55933, >99%;KU 55933, >=98%;KU55933; KU 55933;KU-55933 USP/EP/BP;ATM Kinase Inhibitor;KU-55933 (ATM Kinase Inhibitor)
CBNumber: CB8503709
Molecular Formula: C21H17NO3S2
Formula Weight: 395.49
MOL File: 587871-26-9.mol

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KU-55933 Property

Boiling point:: 628.0±55.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
form: powder
pka: 0.33±0.20(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1109
Product name: KU-55933
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $103
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1109
Product name: KU-55933
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $417
Updated: 2024/03/01

Cayman Chemical

Product number: 16336
Product name: Ku-55933
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 16336
Product name: Ku-55933
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 16336
Product name: Ku-55933
Purity: ≥98%
Packaging: 25 mg
Price: $241
Updated: 2024/03/01

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KU-55933 Chemical Properties,Usage,Production

Description

Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1?levels?in vitro.2?Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3?Sensitizes radio-resistant cancer cells.4Provides neuroprotection against H2O2-induced cell damage.5

Uses

A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.

Uses

KU-55933 has been used as an ataxia-telangiectasia mutated (Atm) inhibitor.

Definition

ChEBI: 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone is a thianthrene.

Biological Activity

Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.

Biochem/physiol Actions

KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.

storage

Desiccate at -20°C

References

1) Hickson?et al.?(2004),?Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM; Cancer Res.,?64?9152 2) Crescenzi?et al.?(2008),?Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy; Clin. Cancer Res.?14?1877 3) Eaton?et al.?(2007),?Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis; J. Clin. Invest.,?117?2723 4) Zhang?et al.?(2015)?The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect; Int. J. Radiat. Biol.,?91?368 5) Chwastek?et al.?(2017)?The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a yH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D; Int. J. Biochem. Cell Biol.?87?38

KU-55933 Preparation Products And Raw materials

Raw materials

Preparation Products

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KU-55933 Suppliers

China 126 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 21 Global 154

AdooQ BioScience, LLC

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Target molecule Corp.

Tel: 857-239-0968
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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

Tel: +1 (732)236-3202
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Aladdin Scientific

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Selleck Chemicals LLC

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CHEMDEA

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Focus Biomolecules

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Abcam

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Matrix Scientific

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Santa Cruz Biotechnology, Inc.

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AK Scientific, Inc.

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Exlcusive Chemistry Ltd

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View Lastest Price from KU-55933 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: KU55933;ku-55933 587871-26-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 10kgs
Release date: 2021-05-24

Career Henan Chemical Co

Product: KU-55933 587871-26-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

587871-26-9, KU-55933Related Search:

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2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

KU-55933 (ATM Kinase Inhibitor)

KU-55933, >99%

KV-55933

2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor)

KU 55933, >=98%

U-55933

ATM Kinase Inhibitor

KU-55933 (ATM KINASE INHIBITOR);KU 55933; KU55933

CS-63

KU55933; KU 55933

KU 55933 NEW

4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)-

KU-55933 USP/EP/BP

ATM Kinase Inhibitor Ku-55933 Ku55933

KU55933,Inhibitor,inhibit,Ataxia telangiectasia mutated,KU-55933,KU 55933,ATM/ATR,ATM and RAD3 related,Autophagy

KU-55933, competitive ATM kinase inhibitor

587871-26-9

C21H17NO3S2

Inhibitors