ChemicalBook > CAS DataBase List > Isopropylamine

Isopropylamine

Product Name
Isopropylamine
CAS No.
75-31-0
Chemical Name
Isopropylamine
Synonyms
MIPA;MONOISOPROPYLAMINE;2-Propanamine;2-Propylamine;Isopropylamine Anhydrous;sopropylamine;MIPA-70;nsc62775;iso-C3H7NH2;i-Propylamin
CBNumber
CB8854223
Molecular Formula
C3H9N
Formula Weight
59.11
MOL File
75-31-0.mol
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Isopropylamine Property

Melting point:
-101 °C
Boiling point:
32-35 °C 33-34 °C (lit.)
Density 
0.688 g/mL at 20 °C (lit.)
vapor density 
2.04 (vs air)
vapor pressure 
9.2 psi ( 20 °C)
refractive index 
n20/D 1.374(lit.)
FEMA 
4238 | ISOPROPYLAMINE
Flash point:
−26 °F
storage temp. 
2-8°C
solubility 
1000g/l
form 
Crystalline Powder, Needles or Crystals
pka
10.63(at 25℃)
color 
APHA: ≤50
PH
13 (700g/l, H2O, 20℃)
Odor
Strong ammoniacal; pungent, irritating, typical amine.
Odor Threshold
0.025ppm
Odor Type
fishy
explosive limit
2-10.4%(V)
Water Solubility 
soluble
Sensitive 
Air Sensitive
JECFA Number
1581
Merck 
14,5209
BRN 
605259
Exposure limits
TLV-TWA 5 ppm (～12 mg/m3) (ACGIH, MSHA, and OSHA); TLV-STEL 10 ppm(～24 mg/m3) (ACGIH); IDLH 4000 ppm (NIOSH).
Dielectric constant
5.5（20℃）
Stability:
Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.
LogP
0.21
CAS DataBase Reference
75-31-0(CAS DataBase Reference)
NIST Chemistry Reference
2-Propanamine(75-31-0)
EPA Substance Registry System
Isopropylamine (75-31-0)
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Safety

Hazard Codes 
F+,Xi,T
Risk Statements 
12-36/37/38-37-35-25-20/21
Safety Statements 
16-26-29-45-36/37/39
RIDADR 
UN 1221 3/PG 1
WGK Germany 
1
RTECS 
NT8400000
F 
34
Autoignition Temperature
755 °F
TSCA 
Yes
HS Code 
2921 19 99
HazardClass 
3
PackingGroup 
I
Hazardous Substances Data
75-31-0(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 820 mg/kg (Smyth)
IDLA
750 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H224Extremely flammable liquid and vapour

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.07476
Product name
Isopropylamine
Purity
for synthesis
Packaging
100mL
Price
$34.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07476
Product name
Isopropylamine
Purity
for synthesis
Packaging
1L
Price
$60.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.07476
Product name
Isopropylamine
Purity
for synthesis
Packaging
2.5L
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
471291
Product name
Isopropylamine
Purity
≥99.5%
Packaging
1l
Price
$47.9
Updated
2024/03/01
Sigma-Aldrich
Product number
471291
Product name
Isopropylamine
Purity
≥99.5%
Packaging
2l
Price
$74.5
Updated
2024/03/01
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Isopropylamine Chemical Properties,Usage,Production

Description

Isopropylamine (propan-2-amine, IUPAC) is a colorless, volatile liquid. It is highly flammable, with a flammable range of 2%–10.4% in air. Boiling point is 93°F (33°C), flash point is ?15°F (?26°C), and ignition temperature is 756°F (402°C).
It is miscible with water, with a specific gravity of 0.69, which is lighter than water. Vapor density is 2.04, which is heavier than air. In addition to flammability, isopropylamine is a strong irritant to tissue and has a TLV of 5 ppm in air. The four-digit UN identification number is 1221. The NFPA 704 designation for isopropylamine is health 3, flammability 4, and reactivity 0. Primary uses for isopropylamine are pharmaceuticals, dyes, insecticides, and as a dehairing agent.

Chemical Properties

Isopropylamine is a colorless, flammable liquid. Isopropylamine is miscible with water, alcohol, and ether.The odor threshold reportedly ranges from 0.21 to 0.70 ppm; the pungent, ammoniacal odor becomes irritating at 24mg/m3 (110).

Physical properties

Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 500 μg/m3 (210 ppbv) and 1.7 mg/m3 (700 ppbv), respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppbv was reported by Nagata and Takeuchi (1990).

Occurrence

Not reported found in natu

Uses

Isopropylamine is an organic compound is a widely used for the synthesis of pharmaceutical and agricultural goods such as glyphosphate herbicides and as an additive for petroleum industry. such as bentazon (BASF), Roundup (Monsanto), imazapyr (ACC) and the triazines ametryne (Novartis), atrazine (Novartis), desmetryn (Novartis), prometryn (Novartis), pramitol (Novartis), dipropetryn (Novartis), and propazine. Other applications encompass the nematicide fenamiphos (Bayer), the fungicide iprodione (Rho?ne-Poulenc), insecticides, pharmaceuticals, and surfactants.

Uses

Isopropylamine is used as a dehairing agentand as an intermediate in the preparation ofmany organics.

Uses

Solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid.

Production Methods

Isopropylamine can be produced from the corresponding alcohol by reacting with ammonia in the presence of a dehydrating catalyst, or from the chloride by reacting with ammonia under pressure. It is also reported that this amine can be produced from acetone and ammonia or from the acetone oxime (HSDB 1989).

Definition

ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.

Aroma threshold values

High strength odor; fishy type; recommend smelling in a 0.10% solution or less.

General Description

A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.

Air & Water Reactions

Highly flammable. Water soluble.

Reactivity Profile

Isopropylamine is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Isopropylamine emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of Isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].

Hazard

Highly flammable, dangerous fire risk. Strong irritant to tissue.

Health Hazard

Isopropylamine is a strong irritant to theeyes, skin, and respiratory system. A shortexposure to 10–20 ppm can cause irritationof the nose and throat in humans (Procturand Hughes 1978). Prolonged exposure tohigh concentrations may lead to pulmonaryedema. Skin contact can cause dermatitisand skin burns. Exposure to 8000 ppm for4 hours was lethal to rats.
LD50 value, oral (mice): 2200 mg/kg.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Industrial uses

Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use as an intermediate in the production of insecticides, herbicides and bactericides and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB 1989).

Environmental Fate

Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987). Forms water-soluble salts with acids.

Metabolism

One would expect isopropylamine to be readily absorbed from the gut and respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are efficiently absorbed through the skin (Beard and Noe 1981). When administered intravenously, isopropylamine distributed rapidly into tissue compartments with tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla (Privitera et al 1982). During the elimination phase, a half-life of 146 min was observed in plasma. There do not appear to be any definitive metabolic studies with this compound, however through a comparison with other substrates, one might expect oxidation to acetone and ammonia through the action of monoamine oxidase (Tipton 1980).

Isopropylamine Preparation Products And Raw materials

Raw materials

Acetone Nickel aluMinuM Barium hydroxide Diisopropylamine KAOLIN Isopropyl alcohol Ammonia

Preparation Products

Befunolol N-T-BUTYL-N'-ISOPROPYLTHIOUREA Solvent Blue 36 DIPROPETRYN CARAZOLOL HCL Prometryn 1-Isopropyl-4-piperidone (-)-2-BETA-CARBOMETHOXY-3-BETA-(4-FLUOROPHENYL)TROPANE N-Isopropylacrylamide Orciprenaline N-ISOPROPYLNORTROPINYL A HYDROXYMETHYL)PHENYLACETATE Ethyl 3-(isopropylamino)propanoate N-(2-METHOXYETHYL)METHYLAMINE Ametryn Pindolol Propyl isocyanate Nilutamide 1-ISOPROPYL-5-HYDROXYPYRAZOL 2-BROMO-3-FORMYLPYRIDINE ISOFENPHOS-METHYL U-47319 Buprofezin 3-MORPHOLIN-4-YL-PROPIONIC ACID 8-isopropyl-8-azabicyclo[3.2.1]oct-3-yl endo-(±)-formylphenylacetate Diisopropylamine 4-(BROMOMETHYL)-N-(L-METHYLETHYL)BENZAMIDE AMIPROFOS METHYL Atrazine ISOFENPHOS Iprodione Fenamiphos Bentazone 4-(4-(Chlorophenyl)imino)-1-isopropyl piperidine Lorcainide Clorprenaline N-(4-chlorophenyl)-1-isopropylpiperidin-4-amine 1-(3,4-dihydroxyphenyl)-2-[(1-methylethyl)amino]ethan-1-one
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Isopropylamine Suppliers

Americas 1 Australia 2 Belgium 5 Canada 2 Chile 1 China 250 Denmark 1 Europe 4 France 2 Germany 15 Hungary 1 India 72 Japan 6 Malaysia 1 Mexico 1 Poland 1 Russia 2 Slovakia 1 South Korea 2 Spain 3 Switzerland 2 The Netherlands 3 Ukraine 1 United Kingdom 13 United States 62 Global 454
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View Lastest Price from Isopropylamine manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Isopropylamine 75-31-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01
Hebei Mojin Biotechnology Co.,Ltd
Product
Isopropylamine 75-31-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-05-23
Hebei Mojin Biotechnology Co., Ltd
Product
Isopropylamine 75-31-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-22

75-31-0, IsopropylamineRelated Search:

Diethylamine Glucosamine Pyrimethamine N,N-Dimethylethylamine Epichlorohydrin Etamsylate EC 2.6.1.2 Trimethylolpropane Propylamine L-1-Phenylethylamine Ethambutol Propylene oxide Sulfamic acid Triethylamine Acetaminophen Sodium propan-2-olate Isopropyl alcohol Amino-2-propanol

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