2,4-Dichloro-5-methoxyaniline
- Product Name
- 2,4-Dichloro-5-methoxyaniline
- CAS No.
- 98446-49-2
- Chemical Name
- 2,4-Dichloro-5-methoxyaniline
- Synonyms
- 5-Amino-2,4-d;Bosutinib Impurity 12;Bosutinib Impurity 25;4,6-Dichloro-m-anisidine;Bosutinib Impurity 12 CRS;5-AMINO-4,6-DICHLOROANISOLE;5-Amino-2,4-Dichloroanisole;2,4-DICHLORO-5-METHOXYANILINE;2,4-Dichloro-5-methhoxyaniline;5-Amino-2,4-dichloroanisole >
- CBNumber
- CB9130874
- Molecular Formula
- C7H7Cl2NO
- Formula Weight
- 192.04
- MOL File
- 98446-49-2.mol
2,4-Dichloro-5-methoxyaniline Property
- Melting point:
- 51 °C
- Boiling point:
- 290.1±35.0 °C(Predicted)
- Density
- 1.375±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.59±0.10(Predicted)
- color
- Pale Brown
- InChIKey
- AJROJTARXSATEB-UHFFFAOYSA-N
- CAS DataBase Reference
- 98446-49-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- UN2810
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A2085
- Product name
- 5-Amino-2,4-dichloroanisole
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- A2085
- Product name
- 5-Amino-2,4-dichloroanisole
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $242
- Updated
- 2025/07/31
- Product number
- D434815
- Product name
- 2,4-Dichloro-5-methoxyaniline
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D434815
- Product name
- 2,4-Dichloro-5-methoxyaniline
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 044492
- Product name
- 2,4-Dichloro-5-methoxyaniline
- Purity
- >95%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
2,4-Dichloro-5-methoxyaniline Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile
Synthesis
2,4-Dichloro-5-methoxyaniline is mainly used to prepare bosutinib intermediate 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(3-chloropropoxy)-3-quinolinecarbonitrile
Synthesis
65182-98-1
98446-49-2
General procedure for the synthesis of 2,4-dichloro-5-methoxyaniline from N-(2,4-dichloro-5-methoxyphenyl)acetamide: N-(2,4-dichloro-5-methoxyphenyl)acetamide (100.7 g, 0.43 mol) was suspended in a mixture of ethanol (500 g), water (500 g), and concentrated hydrochloric acid (300 g, 3 mol), stirred and heated to 70 °C and the reaction lasted for 12 h to obtain a brown solution. After completion of the reaction, ethanol (about 200 g) was evaporated under reduced pressure and the remaining mixture was stirred and cooled to room temperature. After standing for 2 h, the precipitated solid was collected by filtration, washed with water (2 x 200 g) and dried under vacuum at 35 °C to afford 2,4-dichloro-5-methoxyaniline (69.4 g, 84% yield) as a light tan solid with a melting point of 49.5-51.1 °C (literature value 50.5-51.5 °C). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): 1H NMR δ= 3.76 (s, 3H), 5.13 (br s, 2H), 6.58 (s, 1H), 7.23 (s, 1H); mass spectrum (EI) m/z (relative abundance) = 191 (100).
References
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3133 - 3138
[2] Journal of the American Chemical Society, 1919, vol. 41, p. 460
2,4-Dichloro-5-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Dichloro-5-methoxyaniline Suppliers
- Tel
- --
- Fax
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- vi@vuos.com
- Country
- Czech Republic
- ProdList
- 64
- Advantage
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View Lastest Price from 2,4-Dichloro-5-methoxyaniline manufacturers
- Product
- 2,4-Dichloro-5-methoxyaniline 98446-49-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-04-24
- Product
- 2,4-Dichloro-5-methoxyaniline 98446-49-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2019-03-28
- Product
- 2,4-Dichloro-5-methoxyaniline 98446-49-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10