ChemicalBook > CAS DataBase List > 4-Fluoro-2-methylaniline

4-Fluoro-2-methylaniline

Product Name: 4-Fluoro-2-methylaniline
CAS No.: 452-71-1
Chemical Name: 4-Fluoro-2-methylaniline
Synonyms: 2-AMINO-5-FLUOROTOLUENE;4-Fluoro-2-methylbenzenamine;4-fluorotoluidine;4-FLUORO-O-TOLUIDINE;2-Fluoro-o-toluidine;4-Fluoro-2-methylani;o-Toluidine, 4-fluoro-;6-Amino-3-fluorotoluene;3-FLUORO-6-AMINOTOLUENE;2-Methyl-4-fluoroaniline
CBNumber: CB9159888
Molecular Formula: C7H8FN
Formula Weight: 125.14
MOL File: 452-71-1.mol

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4-Fluoro-2-methylaniline Property

Melting point:: 14.2°C
Boiling point:: 90-92 °C/16 mmHg (lit.)
Density: 1.126 g/mL at 25 °C (lit.)
refractive index: n20/D 1.537(lit.)
Flash point:: 190 °F
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 4.51±0.10(Predicted)
form: clear liquid
color: Light yellow to Yellow to Orange
Specific Gravity: 1.126
BRN: 1931798
CAS DataBase Reference: 452-71-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-fluoro-2-methyl-(452-71-1)
EPA Substance Registry System: 4-Fluoro-2-methylaniline (452-71-1)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45-36
RIDADR: 2810
WGK Germany: 3
RTECS: CY0500000
Hazard Note: Toxic/Irritant
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code: 29214300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 189243
Product name: 4-Fluoro-2-methylaniline
Purity: 96%
Packaging: 5g
Price: $37
Updated: 2023/06/20

Sigma-Aldrich

Product number: 189243
Product name: 4-Fluoro-2-methylaniline
Purity: 96%
Packaging: 25g
Price: $76.3
Updated: 2023/01/07

TCI Chemical

Product number: F0398
Product name: 4-Fluoro-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: F0398
Product name: 4-Fluoro-2-methylaniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $102
Updated: 2025/07/31

TRC

Product number: F593065
Product name: 4-Fluoro-2-methylaniline
Packaging: 25g
Price: $105
Updated: 2021/12/16

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4-Fluoro-2-methylaniline Chemical Properties,Usage,Production

Chemical Properties

colorlesstolightyellowliqui

Uses

4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline.

Synthesis

446-33-3

452-71-1

General procedure for the synthesis of 4-fluoro-2-methylaniline from 5-fluoro-2-nitrotoluene: 10% palladium/carbon (Pd/C, 21 mg, 0.020 mmol) was added to a solution of 4-fluoro-2-methyl-1-nitrobenzene (3b, 243 mL, 2.00 mmol) in methanol (MeOH, 10 mL). The reaction mixture was stirred at room temperature and bubbled with hydrogen (H2) for 2 hours. Upon completion of the reaction, the solid catalyst was removed by filtration and the solids were washed with dichloromethane (DCM, 25 mL). The filtrate and DCM wash solution were combined and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, petroleum ether (P.E.) gradient elution to petroleum ether:ethyl acetate (PE:EtOAc) 4:1) to afford 4-fluoro-2-methylaniline (4b) as a pink oil (250 mg, 100% yield).

References

[1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 539 - 550
[2] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[3] Synlett, 2007, # 16, p. 2557 - 2558
[4] Acta Chemica Scandinavica (1947-1973), 1955, vol. 9, p. 1079,1083
[5] Chemische Berichte, 1929, vol. 62, p. 1804

4-Fluoro-2-methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products

5-FLUORO-2-HYDROXY-3-METHYLBENZALDEHYDE

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View Lastest Price from 4-Fluoro-2-methylaniline manufacturers

RongNa Biotechnology Co.,Ltd

Product: 4-Fluoro-2-methylaniline 452-71-1
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-28

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Fluoro-2-methylaniline 452-71-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluoro-2-methylaniline 452-71-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

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Building Blocks

Amines

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Halogen toluene

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Fluorin-contained toluene series

Aniline series