4-Fluoro-2-methylaniline
- Product Name
- 4-Fluoro-2-methylaniline
- CAS No.
- 452-71-1
- Chemical Name
- 4-Fluoro-2-methylaniline
- Synonyms
- 2-AMINO-5-FLUOROTOLUENE;4-Fluoro-2-methylbenzenamine;4-fluorotoluidine;4-FLUORO-O-TOLUIDINE;2-Fluoro-o-toluidine;4-Fluoro-2-methylani;o-Toluidine, 4-fluoro-;6-Amino-3-fluorotoluene;3-FLUORO-6-AMINOTOLUENE;2-Methyl-4-fluoroaniline
- CBNumber
- CB9159888
- Molecular Formula
- C7H8FN
- Formula Weight
- 125.14
- MOL File
- 452-71-1.mol
4-Fluoro-2-methylaniline Property
- Melting point:
- 14.2°C
- Boiling point:
- 90-92 °C/16 mmHg (lit.)
- Density
- 1.126 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.537(lit.)
- Flash point:
- 190 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 4.51±0.10(Predicted)
- form
- clear liquid
- color
- Light yellow to Yellow to Orange
- Specific Gravity
- 1.126
- BRN
- 1931798
- CAS DataBase Reference
- 452-71-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 4-fluoro-2-methyl-(452-71-1)
- EPA Substance Registry System
- 4-Fluoro-2-methylaniline (452-71-1)
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 20/21/22-36/37/38-23/24/25
- Safety Statements
- 26-36/37/39-45-36
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- CY0500000
- Hazard Note
- Toxic/Irritant
- TSCA
- T
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 189243
- Product name
- 4-Fluoro-2-methylaniline
- Purity
- 96%
- Packaging
- 5g
- Price
- $37
- Updated
- 2023/06/20
- Product number
- 189243
- Product name
- 4-Fluoro-2-methylaniline
- Purity
- 96%
- Packaging
- 25g
- Price
- $76.3
- Updated
- 2023/01/07
- Product number
- F0398
- Product name
- 4-Fluoro-2-methylaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- F0398
- Product name
- 4-Fluoro-2-methylaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $102
- Updated
- 2025/07/31
- Product number
- F593065
- Product name
- 4-Fluoro-2-methylaniline
- Packaging
- 25g
- Price
- $105
- Updated
- 2021/12/16
4-Fluoro-2-methylaniline Chemical Properties,Usage,Production
Chemical Properties
colorlesstolightyellowliqui
Uses
4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline.
Synthesis
446-33-3
452-71-1
General procedure for the synthesis of 4-fluoro-2-methylaniline from 5-fluoro-2-nitrotoluene: 10% palladium/carbon (Pd/C, 21 mg, 0.020 mmol) was added to a solution of 4-fluoro-2-methyl-1-nitrobenzene (3b, 243 mL, 2.00 mmol) in methanol (MeOH, 10 mL). The reaction mixture was stirred at room temperature and bubbled with hydrogen (H2) for 2 hours. Upon completion of the reaction, the solid catalyst was removed by filtration and the solids were washed with dichloromethane (DCM, 25 mL). The filtrate and DCM wash solution were combined and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, petroleum ether (P.E.) gradient elution to petroleum ether:ethyl acetate (PE:EtOAc) 4:1) to afford 4-fluoro-2-methylaniline (4b) as a pink oil (250 mg, 100% yield).
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 539 - 550
[2] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[3] Synlett, 2007, # 16, p. 2557 - 2558
[4] Acta Chemica Scandinavica (1947-1973), 1955, vol. 9, p. 1079,1083
[5] Chemische Berichte, 1929, vol. 62, p. 1804
4-Fluoro-2-methylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
4-Fluoro-2-methylaniline Suppliers
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View Lastest Price from 4-Fluoro-2-methylaniline manufacturers
- Product
- 4-Fluoro-2-methylaniline 452-71-1
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-08-28
- Product
- 4-Fluoro-2-methylaniline 452-71-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-01
- Product
- 4-Fluoro-2-methylaniline 452-71-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29