ML-7 HYDROCHLORIDE
- Product Name
- ML-7 HYDROCHLORIDE
- CAS No.
- 110448-33-4
- Chemical Name
- ML-7 HYDROCHLORIDE
- Synonyms
- ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
- CBNumber
- CB9183931
- Molecular Formula
- C15H18ClIN2O2S
- Formula Weight
- 452.74
- MOL File
- 110448-33-4.mol
ML-7 HYDROCHLORIDE Property
- Melting point:
- 246-249°C dec.
- storage temp.
- -20°C
- solubility
- insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
- form
- powder
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- I2764
- Product name
- ML-7
- Purity
- powder
- Packaging
- 5mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 475880
- Product name
- ML-7, Hydrochloride
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2023/06/20
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2024/03/01
ML-7 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
ML-
Chemical Properties
Off-White to Yellow Fine Crystalline Solid
Uses
A potent and selective inhibitor of myosin light chain kinase.
Uses
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
in vitro
rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
in vivo
administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
storage
room temperature (desiccate)
References
[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
ML-7 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ML-7 HYDROCHLORIDE manufacturers
- Product
- ML-7 HYDROCHLORIDE 110448-33-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23