ChemicalBook > CAS DataBase List > 2-Bromonicotinic acid

2-Bromonicotinic acid

Product Name
2-Bromonicotinic acid
CAS No.
35905-85-2
Chemical Name
2-Bromonicotinic acid
Synonyms
AURORA 23320;2-Bromo Niacin;AKOS BBS-00001340;IFLAB-BB F1921-0015;2-BROMONICOTINIC ACID;2-BROMONICOTINIC ACID 98%;2-Bromonicotinic Acid >2-Bromonicotinic acid ,99%;2-Bromonicotinic acid, 96%;2-Bromo-3-pyridine carboxylic
CBNumber
CB9218242
Molecular Formula
C6H4BrNO2
Formula Weight
202.01
MOL File
35905-85-2.mol
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2-Bromonicotinic acid Property

Melting point:
200-203 °C(lit.)
Boiling point:
339.3±27.0 °C(Predicted)
Density 
1.813±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
2.12±0.10(Predicted)
color 
White to Light yellow to Light orange
CAS DataBase Reference
35905-85-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29173990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
632465
Product name
2-Bromopyridine-3-carboxylic acid
Purity
97%
Packaging
5g
Price
$22.75
Updated
2025/07/31
Sigma-Aldrich
Product number
632465
Product name
2-Bromopyridine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$27
Updated
2023/06/20
TCI Chemical
Product number
B2626
Product name
2-Bromonicotinic Acid
Purity
>98.0%(GC)
Packaging
1g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
B2626
Product name
2-Bromonicotinic Acid
Purity
>98.0%(GC)
Packaging
5g
Price
$88
Updated
2025/07/31
TRC
Product number
B686043
Product name
2-Bromonicotinic Acid
Packaging
5g
Price
$75
Updated
2021/12/16
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2-Bromonicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Synthesis

3430-17-9

35905-85-2

General procedure for the synthesis of 2-bromonicotinic acid from 2-bromo-3-methylpyridine: 2-bromo-3-methylpyridine (25.0 mL, 213 mmol) was slowly added to a solution of potassium permanganate (87.7 g, 555 mmol) dissolved in 800 mL of water, and the mixture was stirred continuously for 5 hours under reflux conditions. Upon completion of the reaction, 600 mL of water was removed by distillation and the remaining suspension was separated by thermal filtration. The filtrate was washed with two portions of 50 mL of hot water, and the combined filtrates were acidified with concentrated hydrochloric acid to pH < 2. The precipitate was collected by filtration and dried in a vacuum drying oven to give 26.8 g of 2-bromonicotinic acid in 62% yield. Diphenylphosphoryl chloride was added dropwise to a solution of 2-bromonicotinic acid (15.0 g, 74.0 mmol) and triethylamine (11.4 mL, 81.4 mmol) dissolved in 140 mL of anhydrous tert-butanol. The reaction mixture was stirred under reflux conditions for 2 h. It was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in 150 mL of ethyl acetate and washed sequentially with three parts of 50 mL of water, three parts of 50 mL of saturated aqueous sodium bicarbonate solution and two parts of 50 mL of saturated saline. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. After static crystallization 15.3 g of the target product was obtained in 76% yield.

References

[1] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 165
[4] Tetrahedron, 2015, vol. 71, # 2, p. 252 - 258
[5] Journal of Organic Chemistry, 1949, vol. 14, p. 509,513

2-Bromonicotinic acid Preparation Products And Raw materials

Raw materials

Potassium permanganate 2-Bromo-3-methylpyridine

Preparation Products

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View Lastest Price from 2-Bromonicotinic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Bromonicotinic acid 35905-85-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Henan Fengda Chemical Co., Ltd
Product
2-Bromonicotinic acid 35905-85-2
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Hebei Zhanyao Biotechnology Co. Ltd
Product
2-Bromonicotinic acid 35905-85-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-14

35905-85-2, 2-Bromonicotinic acidRelated Search:

5-BROMOPYRIDINE-3-CARBOXYLIC ACID / 5-BROMONICOTINIC ACID,5-BROMONICOTINIC ACID,5-Bromonicotinic acid, 5-Bromopyridine-3-carboxylic acid N,N-Dimethylpropionamide 2,2-Dimethylbutyryl chloride 2-Phenylbutyric acid 2-Bromopyridine-5-carbaldehyde 5-BROMONICOTINIC ACID ETHYL ESTER,5-Bromonicotinic acid ethyl ester 97%,Ethyl 5-Bromonicotinic acid ethyl ester 6-Hydroxy-5-bromonicotinic acid t-butyl 6-bromo-3-pyridinecarboxylate Methyl 2-amino-5-bromonicotinate 5-Bromonicotinonitrile 2,5-DIBROMONICOTINIC ACID 2-Bromo-5-chloronicotinic acid 5-Bromonicotinic acid methyl ester, 5-Bromopyridine-3-carboxylic acid methyl ester, Methyl 5-bromonicotinate 2-Hydroxy-5-bromonicotinic acid 5-Bromonicotinamide METHYL 6-AMINO-5-BROMONICOTINATE 2-AMINO-5-BROMONICOTINIC ACID,2-Amino-5-bromonicotinic acid 95%,2-Amino-5-bromonicotinic acid ,97% Methyl 5-bromo-2-chloropyridine-3-carboxylate

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