2-Bromonicotinic acid
- Product Name
- 2-Bromonicotinic acid
- CAS No.
- 35905-85-2
- Chemical Name
- 2-Bromonicotinic acid
- Synonyms
- AURORA 23320;2-Bromo Niacin;AKOS BBS-00001340;IFLAB-BB F1921-0015;2-BROMONICOTINIC ACID;2-BROMONICOTINIC ACID 98%;2-Bromonicotinic Acid >2-Bromonicotinic acid ,99%;2-Bromonicotinic acid, 96%;2-Bromo-3-pyridine carboxylic
- CBNumber
- CB9218242
- Molecular Formula
- C6H4BrNO2
- Formula Weight
- 202.01
- MOL File
- 35905-85-2.mol
2-Bromonicotinic acid Property
- Melting point:
- 200-203 °C(lit.)
- Boiling point:
- 339.3±27.0 °C(Predicted)
- Density
- 1.813±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 2.12±0.10(Predicted)
- color
- White to Light yellow to Light orange
- CAS DataBase Reference
- 35905-85-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29173990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 632465
- Product name
- 2-Bromopyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $22.75
- Updated
- 2025/07/31
- Product number
- 632465
- Product name
- 2-Bromopyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $27
- Updated
- 2023/06/20
- Product number
- B2626
- Product name
- 2-Bromonicotinic Acid
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $24
- Updated
- 2025/07/31
- Product number
- B2626
- Product name
- 2-Bromonicotinic Acid
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- B686043
- Product name
- 2-Bromonicotinic Acid
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
2-Bromonicotinic acid Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Synthesis
3430-17-9
35905-85-2
General procedure for the synthesis of 2-bromonicotinic acid from 2-bromo-3-methylpyridine: 2-bromo-3-methylpyridine (25.0 mL, 213 mmol) was slowly added to a solution of potassium permanganate (87.7 g, 555 mmol) dissolved in 800 mL of water, and the mixture was stirred continuously for 5 hours under reflux conditions. Upon completion of the reaction, 600 mL of water was removed by distillation and the remaining suspension was separated by thermal filtration. The filtrate was washed with two portions of 50 mL of hot water, and the combined filtrates were acidified with concentrated hydrochloric acid to pH < 2. The precipitate was collected by filtration and dried in a vacuum drying oven to give 26.8 g of 2-bromonicotinic acid in 62% yield. Diphenylphosphoryl chloride was added dropwise to a solution of 2-bromonicotinic acid (15.0 g, 74.0 mmol) and triethylamine (11.4 mL, 81.4 mmol) dissolved in 140 mL of anhydrous tert-butanol. The reaction mixture was stirred under reflux conditions for 2 h. It was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in 150 mL of ethyl acetate and washed sequentially with three parts of 50 mL of water, three parts of 50 mL of saturated aqueous sodium bicarbonate solution and two parts of 50 mL of saturated saline. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. After static crystallization 15.3 g of the target product was obtained in 76% yield.
References
[1] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 165
[4] Tetrahedron, 2015, vol. 71, # 2, p. 252 - 258
[5] Journal of Organic Chemistry, 1949, vol. 14, p. 509,513
2-Bromonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromonicotinic acid Suppliers
- Tel
- --
- Fax
- --
- interchim@interchim.com
- Country
- France
- ProdList
- 6302
- Advantage
- 76
View Lastest Price from 2-Bromonicotinic acid manufacturers
- Product
- 2-Bromonicotinic acid 35905-85-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-12
- Product
- 2-Bromonicotinic acid 35905-85-2
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Bromonicotinic acid 35905-85-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-14