Dihydrocholesterol

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Dihydrocholesterol

Product Name: Dihydrocholesterol
CAS No.: 80-97-7
Chemical Name: Dihydrocholesterol
Synonyms: CHOLESTANOL;β-Cholestanol;BETA-CHOLESTANOL;5alpha-Cholestanol;Cholestan-3beta-ol;5A-CHOLESTAN-3B-OL;5α-Cholestan-3β-ol;5ALPHA-CHOLESTAN-3BETA-OL;10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol;NSC 18188
CBNumber: CB9262856
Molecular Formula: C27H48O
Formula Weight: 388.68
MOL File: 80-97-7.mol

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Dihydrocholesterol Property

Melting point:: 138-142 °C
alpha: D22 +24.2° (c = 1.3 in chloroform)
Boiling point:: 454.32°C (rough estimate)
Density: 0.9506 (rough estimate)
refractive index: 1.5250 (estimate)
storage temp.: -20°C
solubility: chloroform: 0.1 g/mL, clear, colorless
pka: 15.14±0.70(Predicted)
form: A solid
Water Solubility: Insoluble in water.
Merck: 14,2200
BRN: 2418594
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
LogP: 10.065 (est)
CAS DataBase Reference: 80-97-7(CAS DataBase Reference)
NIST Chemistry Reference: Cholestanol(80-97-7)
EPA Substance Registry System: Dihydrocholesterol (80-97-7)

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Safety

Hazard Codes: Xn
Risk Statements: 22-38-40-48/20/22-67-36/38-20-63
Safety Statements: 24/25-36/37-22-26
RIDADR: UN 1888 6.1/PG 3
WGK Germany: 3
RTECS: FZ6350000
TSCA: Yes
HS Code: 2906 13 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D6128
Product name: 5α-Cholestan-3β-ol
Purity: ≥95%
Packaging: 10g
Price: $111
Updated: 2024/03/01

Sigma-Aldrich

Product number: D6128
Product name: 5α-Cholestan-3β-ol
Purity: ≥95%
Packaging: 25g
Price: $258
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41513
Product name: 5α-Cholestan-3ß-ol
Purity: forsynthesis
Packaging: 5G
Price: $114
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47129
Product name: Cholestanol solution
Purity: certified reference material, 10?mg/mL in chloroform
Packaging: 1mL
Price: $55
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1131858
Product name: Cholestanol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200MG
Price: $311
Updated: 2022/05/15

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Dihydrocholesterol Chemical Properties,Usage,Production

Description

Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid . Cholestanol (10 μg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases. Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum. Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.

Chemical Properties

white powder

Uses

5alpha-Cholestan-3beta-ol is used as a standard in lipid analysis using HPLC. It acts as a derivitized steroid compound. It is used in agrochemical, pharmaceutical and dyestuff field .

Uses

5α-Cholestan-3β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. Studies have also examined the conversion of 5α-Cholestan-3β-ol catalyzed by 3-β-hydroxysteroid dehydrogenase of rat liver.

Definition

ChEBI: A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.

General Description

Cholestanol is a 5α-dihydro derivative of cholesterol. It acts as a marker for cholesterol absorption. Cholestanol is a steroid with 27 carbon atoms.

Biochem/physiol Actions

5α-Cholestan-3β-ol is derived from cholesterol by the action of intestinal microorganisms. It is known to induce the formation of gall stones in rabbits in the presence of sodium ions.

Purification Methods

Purify 5--cholestan-3-ol via acetylation, crystallisation and de-acetylation, then recrystallisation from EtOH or slightly aqueous EtOH, or MeOH. Its solubility is: 0.5% (MeOH) and 1% (EtOH) at 25o. [Mizutani & Whitten J Am Chem Soc 107 3621 1985.] The acetate has m 114-115o from EtOAc/MeOH and, [] D 20 +13o (c 2, CHCl3). [Bruce & Ralls Org Synth Col Vol II 191 1943, Beilstein 6 IV 3577.]

Dihydrocholesterol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dihydrocholesterol manufacturers

Career Henan Chemical Co

Product: Dihydrocholesterol 80-97-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-18

Career Henan Chemical Co

Product: MBAA 80-97-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-18

Career Henan Chemical Co

Product: 1,4-Benzenedicarboxylic acid bis(4-aminophenyl) ester 80-97-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-18

80-97-7, DihydrocholesterolRelated Search:

Cholesterol Sodium Phosphate, Dibasic Ammonium dihydrogen phosphate Potassium hydrogen phthalate Aluminum dihydrogen phosphate 5α-Cholestane Dipotassium hydrogen phosphate trihydrate DIHYDROLIPOIC ACID Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate TOMATINE HECOGENIN ACETATE DIGITONIN Hecogenin Tigogenin TOMATIDINE DIHYDROCHOLETH-30 Dihydrocholesteryl oleate Tomatidine hydrochloride

β-Cholestanol (contains α-Cholestanol)

(3beta,5alpha)-cholestan-3-o

5alpha-Cholestanol

5alpha-Dihydrocholesterol

Cholestan-3beta-ol

Cholestan-3-ol, (3beta,5alpha)-

Dihydrocholesterin

BETA-CHOLESTANOL

CHOLESTAN-3-B-OL, (5A)-

CHOLESTANOL

DIHYDROCHOLESTEROL

5ALPHA-CHOLESTAN-3BETA-OL, >=95%

Cholestan-3-ol, (3b,5a)-

5α-Cholestan-3-ol for synthesis

Dihydrocholesterol reference substance

Cholestanol solution

5α-Cholestanol

NSC 18188

5ALPHA-CHOLESTANE-3BETA-OL

5ALPHA-CHOLESTAN-3BETA-OL

(5A)-CHOLESTANOL

5A-CHOLESTAN-3B-OL

3B-CHOLESTANOL

3BETA-HYDROXY-5ALPHA-CHOLESTANE

3BETA-CHOLESTANOL

3B-HYDROXYCHOLESTANE

DIHYDROCHOLESTEROL CRYSTALLINE

3-BETA-CHOLESTANOL (DIHYDROCHOLESTEROL)

5ALPHA-Cholestan-3B-ol

3BETA-CHOLESTANOL 98%

(+)-Dihydrocholesterol solution, 3β-Cholestanol, 3β-Hydroxy-5α-cholestane, 5α-Cholestan-3β-ol

β-Cholestanol, 3β-Hydroxy-5α-cholestane, Dihydrocholesterol

Dihydrocholesterol,96%

CHOLESTAN-3-b-OL, (5a)-(SG)

5α-Cholestan-3β-ol,β-Cholestanol, 3β-Hydroxy-5α-cholestane, Dihydrocholesterol

3á-cholestanol

10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

BETA-CHOLESTANOL (CONTAINS ALPHA-CHOLESTANOL): 92%

3SS-CHOLESTANOL

(contains alpha-Cholestanol)

beta-Cholestanol&nbsp

5a-Cholestan-3-ol-2,2,3a,4,4-d5

β-Cholestanol (contains α-Cholestanol)&gt

5A-CHOLESTAN-3B-OL FOR SYNTHESIS

Cholestan-3-ol, (3β,5α)-

5α-Cholestan-3β-ol

5α-Cholestan-3β-ol (5α-Cholestanol

Cholesterol Impurity 22

5a-Cholestan-3-β-ol

-cholestan-3-B2

β-Cholestanol (contains α-Cholestanol)

(10S,13R)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

β-Cholestanol

5α-Cholestanol

(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-ol

(5a)-Cholestan-3b-OL (AS)

(+)-Dihydrocholesterol

Cholesterol Impurity 18 (Cholestanol)