Dihydrocholesterol
- Product Name
- Dihydrocholesterol
- CAS No.
- 80-97-7
- Chemical Name
- Dihydrocholesterol
- Synonyms
- CHOLESTANOL;β-Cholestanol;BETA-CHOLESTANOL;5alpha-Cholestanol;Cholestan-3beta-ol;5A-CHOLESTAN-3B-OL;5α-Cholestan-3β-ol;5ALPHA-CHOLESTAN-3BETA-OL;10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol;NSC 18188
- CBNumber
- CB9262856
- Molecular Formula
- C27H48O
- Formula Weight
- 388.68
- MOL File
- 80-97-7.mol
Dihydrocholesterol Property
- Melting point:
- 138-142 °C
- alpha
- D22 +24.2° (c = 1.3 in chloroform)
- Boiling point:
- 454.32°C (rough estimate)
- Density
- 0.9506 (rough estimate)
- refractive index
- 1.5250 (estimate)
- storage temp.
- -20°C
- solubility
- chloroform: 0.1 g/mL, clear, colorless
- pka
- 15.14±0.70(Predicted)
- form
- A solid
- color
- White to off-white
- Water Solubility
- Insoluble in water.
- Merck
- 14,2200
- BRN
- 2418594
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- LogP
- 10.065 (est)
- CAS DataBase Reference
- 80-97-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Cholestanol(80-97-7)
- EPA Substance Registry System
- Dihydrocholesterol (80-97-7)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-38-40-48/20/22-67-36/38-20-63
- Safety Statements
- 24/25-36/37-22-26
- RIDADR
- UN 1888 6.1/PG 3
- WGK Germany
- 3
- RTECS
- FZ6350000
- TSCA
- Yes
- HS Code
- 2906 13 10
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H336May cause drowsiness or dizziness
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P281Use personal protective equipment as required.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D6128
- Product name
- 5α-Cholestan-3β-ol
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $111
- Updated
- 2024/03/01
- Product number
- D6128
- Product name
- 5α-Cholestan-3β-ol
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $258
- Updated
- 2024/03/01
- Product number
- 8.41513
- Product name
- 5α-Cholestan-3ß-ol
- Purity
- forsynthesis
- Packaging
- 5G
- Price
- $114
- Updated
- 2024/03/01
- Product number
- 47129
- Product name
- Cholestanol solution
- Purity
- certified reference material, 10?mg/mL in chloroform
- Packaging
- 1mL
- Price
- $55
- Updated
- 2024/03/01
- Product number
- 1131858
- Product name
- Cholestanol
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200MG
- Price
- $311
- Updated
- 2022/05/15
Dihydrocholesterol Chemical Properties,Usage,Production
Description
Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid . Cholestanol (10 μg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases. Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum. Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.
Chemical Properties
white powder
Uses
5alpha-Cholestan-3beta-ol is used as a standard in lipid analysis using HPLC. It acts as a derivitized steroid compound. It is used in agrochemical, pharmaceutical and dyestuff field .
Uses
5α-Cholestan-3β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. Studies have also examined the conversion of 5α-Cholestan-3β-ol catalyzed by 3-β-hydroxysteroid dehydrogenase of rat liver.
Definition
ChEBI: A cholestanoid that is (5alpha)-cholestane substituted by a beta-hydroxy group at position 3.
General Description
Cholestanol is a 5α-dihydro derivative of cholesterol. It acts as a marker for cholesterol absorption. Cholestanol is a steroid with 27 carbon atoms.
Biochem/physiol Actions
5α-Cholestan-3β-ol is derived from cholesterol by the action of intestinal microorganisms. It is known to induce the formation of gall stones in rabbits in the presence of sodium ions.
Purification Methods
Purify 5--cholestan-3-ol via acetylation, crystallisation and de-acetylation, then recrystallisation from EtOH or slightly aqueous EtOH, or MeOH. Its solubility is: 0.5% (MeOH) and 1% (EtOH) at 25o. [Mizutani & Whitten J Am Chem Soc 107 3621 1985.] The acetate has m 114-115o from EtOAc/MeOH and, [] D 20 +13o (c 2, CHCl3). [Bruce & Ralls Org Synth Col Vol II 191 1943, Beilstein 6 IV 3577.]
Dihydrocholesterol Preparation Products And Raw materials
Raw materials
Preparation Products
Dihydrocholesterol Suppliers
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View Lastest Price from Dihydrocholesterol manufacturers
- Product
- Dihydrocholesterol 80-97-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-18
- Product
- MBAA 80-97-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-18
- Product
- 1,4-Benzenedicarboxylic acid bis(4-aminophenyl) ester 80-97-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-18