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2-Bromo-4'-hydroxyacetophenone

Product Name
2-Bromo-4'-hydroxyacetophenone
CAS No.
2491-38-5
Chemical Name
2-Bromo-4'-hydroxyacetophenone
Synonyms
2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
CBNumber
CB9306895
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
2491-38-5.mol
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2-Bromo-4'-hydroxyacetophenone Property

Melting point:
123-126°C
Boiling point:
338.7±17.0 °C(Predicted)
Density 
1.622±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
White powder
pka
7.69±0.15(Predicted)
color 
White to Light Beige
Sensitive 
Lachrymatory
BRN 
1865388
Stability:
Hygroscopic
CAS DataBase Reference
2491-38-5(CAS DataBase Reference)
EPA Substance Registry System
2-Bromo-4-hydroxyacetophenone (2491-38-5)
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Safety

Hazard Codes 
C,Xn
Risk Statements 
22-36
Safety Statements 
26
RIDADR 
1760
WGK Germany 
1
RTECS 
AM5982000
Hazard Note 
Corrosive/Lachrymatory/Keep Cold
HazardClass 
8
PackingGroup 
III
HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS013566
Product name
2-bromo-4′-hydroxyacetophenone
Purity
AldrichCPR
Packaging
1G
Price
$81.6
Updated
2023/06/20
TCI Chemical
Product number
B4115
Product name
2-Bromo-4'-hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
B4115
Product name
2-Bromo-4'-hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
19766
Product name
PTP Inhibitor I
Purity
≥98%
Packaging
5g
Price
$60
Updated
2023/06/20
Cayman Chemical
Product number
19766
Product name
PTP Inhibitor I
Purity
≥98%
Packaging
10g
Price
$112
Updated
2023/06/20
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2-Bromo-4'-hydroxyacetophenone Chemical Properties,Usage,Production

Description

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

Chemical Properties

Pale Beige Solid

Uses

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Preparation

Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.

in vitro

in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].

References

[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.

2-Bromo-4'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-4'-hydroxyacetophenone Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 235 Europe 3 Germany 1 India 14 Japan 2 South Korea 3 Ukraine 1 United Kingdom 15 United States 40 Global 319
Suzhou ChonTech Biopharma Co.,Ltd
Tel
0512-63101022 13912623614
Fax
86-512-6310 1035
Email
sales@chontech.com
Country
Austria
ProdList
219
Advantage
58
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View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $2230.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1T
Release date
2020-06-29
Henan Aochuang Chemical Co.,Ltd.
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

2491-38-5, 2-Bromo-4'-hydroxyacetophenoneRelated Search:

2',4',6'-Trihydroxyacetophenone monohydrate 2'-Hydroxyacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 2-HYDROXYACETOPHENONE Acetophenone 3,5-Dihydroxyacetophenone 3-Amino-2-hydroxyacetophenone 3'-Hydroxyacetophenone 3-Nitroacetophenone 3'-Bromoacetophenone 2',6'-Dihydroxyacetophenone 3-Bromoanisole 2,4-Dihydroxyacetophenone 4'-Methylacetophenone 4'-Hydroxyacetophenone L-PICEIN Bromine

  • PTP INHIBITOR I
  • PROTEIN TYROSINE PHOSPHATASE INHIBITOR I
  • ALPHA-BROMO-4-HYDROXYACETOPHENONE
  • 4-HYDROXYPHENACYL BR
  • 4-HYDROXYPHENACYL BROMIDE
  • 2-BROMO-1-(4-HYDROXY-PHENYL)-ETHANONE
  • 2'-BROMO-4'-HYDROXYACETOPHENONE
  • 2-BROMO-4'-HYDROXYACETOPHENONE
  • 4-Hydroxy α-Bromoacetophenone
  • 4-HYDROXY A-BROMOACETOPHENONE
  • Ethanone, 2-bromo-1-(4-hydroxyphenyl)-
  • A-BROMO-4-HYDROXY ACETOPHENONE
  • 1-(4-hydroxyphenyl)-2-bromoethanone
  • BROMOHYDROXYACETOPHENONE
  • BHAP
  • BUSAN1130
  • BUSAN90
  • 2-Brom-1-(4-hydroxyphenyl)ethan-1-on
  • α-Bromo-4-hydroxyacetophenone
  • 2-bromo-1-(4-hydroxyphenyl)ethan-1-one
  • 4-Hydroxy-alpha-bromoacetophenone
  • 2-Bromo-4-Hydroxyacetophenone98%
  • Alpha broMine generation of hydroxy acetophenone
  • α-broMo p-hydroxyacetophenone
  • 4-(Bromoacetyl)phenol
  • p-Hydroxy α-Bromoacetophenone
  • 2-Bromo-4'-hydroxyacetophenone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one
  • Aipha-BroMo-4-hydroxyacetophenone
  • Butrol 1130
  • p-Hydroxyphenacyl BroMide
  • 4-Hydroxyphenacyl bromide 97%
  • PTP Inhibitor I - CAS 2491-38-5 - Calbiochem
  • 2-Bromo-4'-hydroxyacetophenone &gt
  • SHP-1 Inhibitor II
  • 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I)
  • α-Bromo-4-hydroxyacetophenone
  • 2-Bromo-4'-hydroxyacetophenone
  • Cyclohexane Impurity 5
  • Isavuconazole Impurity N16
  • 2491-38-5
  • Aromatics
  • Inhibitors
  • Aromatic Acetophenones & Derivatives (substituted)