ChemicalBook > CAS DataBase List > 2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone

Product Name
2-Bromo-4'-hydroxyacetophenone
CAS No.
2491-38-5
Chemical Name
2-Bromo-4'-hydroxyacetophenone
Synonyms
2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
CBNumber
CB9306895
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
2491-38-5.mol
More
Less

2-Bromo-4'-hydroxyacetophenone Property

Melting point:
123-126°C
Boiling point:
338.7±17.0 °C(Predicted)
Density 
1.622±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
White powder
pka
7.69±0.15(Predicted)
color 
White to Light Beige
Sensitive 
Lachrymatory
BRN 
1865388
Stability:
Hygroscopic
CAS DataBase Reference
2491-38-5(CAS DataBase Reference)
EPA Substance Registry System
2-Bromo-4-hydroxyacetophenone (2491-38-5)
More
Less

Safety

Hazard Codes 
C,Xn
Risk Statements 
22-36
Safety Statements 
26
RIDADR 
1760
WGK Germany 
1
RTECS 
AM5982000
Hazard Note 
Corrosive/Lachrymatory/Keep Cold
HazardClass 
8
PackingGroup 
III
HS Code 
2914500090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS013566
Product name
2-bromo-4′-hydroxyacetophenone
Purity
AldrichCPR
Packaging
1G
Price
$81.6
Updated
2023/06/20
TCI Chemical
Product number
B4115
Product name
2-Bromo-4'-hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
B4115
Product name
2-Bromo-4'-hydroxyacetophenone
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
19766
Product name
PTP Inhibitor I
Purity
≥98%
Packaging
5g
Price
$60
Updated
2023/06/20
Cayman Chemical
Product number
19766
Product name
PTP Inhibitor I
Purity
≥98%
Packaging
10g
Price
$112
Updated
2023/06/20
More
Less

2-Bromo-4'-hydroxyacetophenone Chemical Properties,Usage,Production

Description

PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.

Chemical Properties

Pale Beige Solid

Uses

A covalent inhibitor of protein tyrosine phosphatases (PTPs)

Preparation

Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.

in vitro

in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].

References

[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.

2-Bromo-4'-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Bromo-4'-hydroxyacetophenone Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 235 Europe 3 Germany 1 India 14 Japan 2 South Korea 3 Ukraine 1 United Kingdom 15 United States 40 Global 319
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3383
Advantage
56
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9499
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
More
Less

View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $2230.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
1T
Release date
2020-06-29
Henan Aochuang Chemical Co.,Ltd.
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Career Henan Chemical Co
Product
2-Bromo-4'-hydroxyacetophenone 2491-38-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

2491-38-5, 2-Bromo-4'-hydroxyacetophenoneRelated Search:

2',4',6'-Trihydroxyacetophenone monohydrate 2'-Hydroxyacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 2-HYDROXYACETOPHENONE Acetophenone 3,5-Dihydroxyacetophenone 3-Amino-2-hydroxyacetophenone 3'-Hydroxyacetophenone 3-Nitroacetophenone 3'-Bromoacetophenone 2',6'-Dihydroxyacetophenone 3-Bromoanisole 2,4-Dihydroxyacetophenone 4'-Methylacetophenone 4'-Hydroxyacetophenone L-PICEIN Bromine

  • PTP INHIBITOR I
  • PROTEIN TYROSINE PHOSPHATASE INHIBITOR I
  • ALPHA-BROMO-4-HYDROXYACETOPHENONE
  • 4-HYDROXYPHENACYL BR
  • 4-HYDROXYPHENACYL BROMIDE
  • 2-BROMO-1-(4-HYDROXY-PHENYL)-ETHANONE
  • 2'-BROMO-4'-HYDROXYACETOPHENONE
  • 2-BROMO-4'-HYDROXYACETOPHENONE
  • 4-Hydroxy α-Bromoacetophenone
  • 4-HYDROXY A-BROMOACETOPHENONE
  • Ethanone, 2-bromo-1-(4-hydroxyphenyl)-
  • A-BROMO-4-HYDROXY ACETOPHENONE
  • 1-(4-hydroxyphenyl)-2-bromoethanone
  • BROMOHYDROXYACETOPHENONE
  • BHAP
  • BUSAN1130
  • BUSAN90
  • 2-Brom-1-(4-hydroxyphenyl)ethan-1-on
  • α-Bromo-4-hydroxyacetophenone
  • 2-bromo-1-(4-hydroxyphenyl)ethan-1-one
  • 4-Hydroxy-alpha-bromoacetophenone
  • 2-Bromo-4-Hydroxyacetophenone98%
  • Alpha broMine generation of hydroxy acetophenone
  • α-broMo p-hydroxyacetophenone
  • 4-(Bromoacetyl)phenol
  • p-Hydroxy α-Bromoacetophenone
  • 2-Bromo-4'-hydroxyacetophenone, 2-Bromo-1-(4-hydroxyphenyl)ethan-1-one
  • Aipha-BroMo-4-hydroxyacetophenone
  • Butrol 1130
  • p-Hydroxyphenacyl BroMide
  • 4-Hydroxyphenacyl bromide 97%
  • PTP Inhibitor I - CAS 2491-38-5 - Calbiochem
  • 2-Bromo-4'-hydroxyacetophenone &gt
  • SHP-1 Inhibitor II
  • 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I)
  • α-Bromo-4-hydroxyacetophenone
  • 2-Bromo-4'-hydroxyacetophenone
  • Cyclohexane Impurity 5
  • Isavuconazole Impurity N16
  • 2491-38-5
  • Aromatics
  • Inhibitors
  • Aromatic Acetophenones & Derivatives (substituted)