ChemicalBook > CAS DataBase List > 2-Bromo-4'-hydroxyacetophenone
2-Bromo-4'-hydroxyacetophenone
- Product Name
- 2-Bromo-4'-hydroxyacetophenone
- CAS No.
- 2491-38-5
- Chemical Name
- 2-Bromo-4'-hydroxyacetophenone
- Synonyms
- 2-bromo-1-(4-hydroxyphenyl)ethan-1-one;BHAP;BUSAN90;BUSAN1130;Butrol 1130;PTP INHIBITOR I;SHP-1 Inhibitor II;4-HYDROXYPHENACYL BR;4-(Bromoacetyl)phenol;Cyclohexane Impurity 5
- CBNumber
- CB9306895
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- 2491-38-5.mol
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2-Bromo-4'-hydroxyacetophenone Property
- Melting point:
- 123-126°C
- Boiling point:
- 338.7±17.0 °C(Predicted)
- Density
- 1.622±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- White powder
- pka
- 7.69±0.15(Predicted)
- color
- White to Light Beige
- Sensitive
- Lachrymatory
- BRN
- 1865388
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 2491-38-5(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Bromo-4-hydroxyacetophenone (2491-38-5)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS013566
- Product name
- 2-bromo-4′-hydroxyacetophenone
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $81.6
- Updated
- 2023/06/20
TCI Chemical
- Product number
- B4115
- Product name
- 2-Bromo-4'-hydroxyacetophenone
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2024/03/01
TCI Chemical
- Product number
- B4115
- Product name
- 2-Bromo-4'-hydroxyacetophenone
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $151
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19766
- Product name
- PTP Inhibitor I
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $60
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 19766
- Product name
- PTP Inhibitor I
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $112
- Updated
- 2023/06/20
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2-Bromo-4'-hydroxyacetophenone Chemical Properties,Usage,Production
Description
PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.
Chemical Properties
Pale Beige Solid
Uses
A covalent inhibitor of protein tyrosine phosphatases (PTPs)
Preparation
Also obtained by reaction of pyridinium hydrobromide perbromide with 4-hydroxyacetophenone in THF at r.t. for 3 h.
in vitro
in previous study, the corresponding values of ptp inhibitor i against ptp1b were determined to be ki of 42 μm, kinact of 0.57 min-1, and kinact/ki of 1.4*104 m-1 min-1, respectively. this study also showed that α-bromoacetophenone such as ptp inhibitor i could provide an effective, neutral py mimetic inhibitor of ptps. while perturbation of the electronic properties of the phenyl ring did not significantly improve its potency against ptps, attachment of a proper peptidyl moiety to the para position could improve both the potency and the selectivity substantially. in addition, since the covalent ptp inhibitor complex could be cleaved to regenerate the ptp activity photolytically, ptp inhibitor i might provide a novel class of photolytic switch for controlling cellular signaling processes [1].
References
[1] arabaci g, yi t, fu h, porter me, beebe kd, pei d. alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-activity relationship. bioorg med chem lett. 2002 nov 4;12(21):3047-50.
2-Bromo-4'-hydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-4'-hydroxyacetophenone manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-Bromo-4'-hydroxyacetophenone 2491-38-5
- Price
- US $2230.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1T
- Release date
- 2020-06-29
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2-Bromo-4'-hydroxyacetophenone 2491-38-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
Career Henan Chemical Co
- Product
- 2-Bromo-4'-hydroxyacetophenone 2491-38-5
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04
2491-38-5, 2-Bromo-4'-hydroxyacetophenoneRelated Search:
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