IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 38922-77-9
- Chemical Name
- IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- ETHYL IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;2-(Ethoxycarbonyl)imidazo[1,2-a]pyridine;ethyl 3-imidazo[1,2-a]pyridine-2-carboxylate;Ethyl imidazo[1,2-a]pyridine-2-carboxylate 97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate ,97%;Ethyl imidazo[1,2-a]pyridine-2-carboxylate;Imidazo-[1,2-A] pyridine-2-carboxylate ethyl ester;IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB9320369
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 38922-77-9.mol
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 79.5-83
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.28±0.50(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C10H10N2O2/c1-2-14-10(13)8-7-12-6-4-3-5-9(12)11-8/h3-7H,2H2,1H3
- InChIKey
- GNFACXDTRBVZJE-UHFFFAOYSA-N
- SMILES
- C12=NC(C(OCC)=O)=CN1C=CC=C2
- CAS DataBase Reference
- 38922-77-9(CAS DataBase Reference)
Safety
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 737550
- Product name
- Ethyl imidazo[1,2-a]pyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $101
- Updated
- 2023/01/07
- Product number
- E919218
- Product name
- Ethyl imidazo[1,2-a]pyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- E919218
- Product name
- Ethyl imidazo[1,2-a]pyridine-2-carboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 044881
- Product name
- Ethyl imidazo[1,2-a]pyridine-2-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- JK289695
- Product name
- Ethyl imidazo[1,2-a]pyridine-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Off-white to brown solid
Synthesis
504-29-0
70-23-5
38922-77-9
Step 1: Synthesis of ethyl imidazo[1,2-a]pyridine-2-carboxylate Under magnetic stirring, 3 g (31.9 mmol) of 2-aminopyridine was dissolved in 65 mL of tetrahydrofuran. 4.44 mL (31.9 mmol) of ethyl 3-bromopyruvate was added slowly and solid precipitate formation was observed. The resulting non-homogeneous mixture was heated to reflux and stirred continuously for 4 hours. Upon completion of the reaction, it was cooled to room temperature and the solid product was isolated by filtration. The solid was dissolved in 65 mL of ethanol and again heated to reflux and stirred for 16 hours. The reaction mixture was cooled to room temperature and the solids were separated by filtration. The filtrate was placed in an ice bath to promote crystallization of the product until the liquid phase remained clear. The crystallized product was collected by filtration and washed with 30 mL of diisopropyl ether. Finally, the product was dried in a vacuum desiccator to afford 5.14 g (84% yield) of ethyl imidazo[1,2-a]pyridine-2-carboxylate as a white powder. Product characterization: LC-MS showed m/z=191 (MH+); UV purity was 99% at 254 nm.1H NMR (300 MHz, DMSO) δ 8.95 (s, 1H), 8.84 (d, J=6.8 Hz, 1H), 7.98-7.80 (m, 2H), 7.46 (t, J=7.2 Hz, 1H), 4.43 ( q, J=7.1Hz, 2H), 1.35 (d, J=7.1Hz, 3H).
References
[1] ACS Combinatorial Science, 2018, vol. 20, # 3, p. 164 - 171
[2] Patent: US2015/182507, 2015, A1. Location in patent: Paragraph 0204; 0205
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362
[4] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 216 - 231
[5] ChemMedChem, 2017, vol. 12, # 3, p. 257 - 270
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers
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View Lastest Price from IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-24
- Product
- IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER 38922-77-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 681
- Release date
- 2019-09-01