2-Cyanopyridine Property

Melting point:

24-27 °C(lit.)

Boiling point:

212-215 °C(lit.)

Density 

1.081 g/mL at 25 °C(lit.)

vapor pressure 

11.96Pa at 25℃

refractive index 

n20/D 1.529(lit.)

Flash point:

193 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

67g/l

form 

Low Melting Crystalline Solid

pka

pK1:-0.26(+1) (25°C)

color 

White to brown

PH

8.4 (100g/l, H2O)

Water Solubility 

immiscible

BRN 

107710

Exposure limits

NIOSH: IDLH 25 mg/m3

Dielectric constant

93.769999999999996

LogP

0.45 at 25℃

CAS DataBase Reference

100-70-9(CAS DataBase Reference)

NIST Chemistry Reference

2-Pyridinecarbonitrile(100-70-9)

EPA Substance Registry System

2-Pyridinecarbonitrile (100-70-9)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-24/25

RIDADR 

3276

WGK Germany 

3

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333999

Hazardous Substances Data

100-70-9(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

2-Cyanopyridine Chemical Properties,Usage,Production

Description

The cyanopyridines are as follows:2-cyano-: A white to tan liquid or solid with an almondodor. Boiling point=about 213℃; Freezing/Meltingpoint=27℃; Flash point=89℃.3-cyano-: A colorless liquid or gray crystalline solid.Molecular weight=104.12; Boiling point=83-84℃;Freezing/Melting point=47-49℃. Hazard Identification(based on NFPA-704 M Rating System): Health 3,Flammability 3, Reactivity 0. Soluble in water.4-cyano-: A beige solid. Freezing/Melting point=75.8℃

Chemical Properties

white to brown low melting crystalline solid

Chemical Properties

The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.

Uses

2-Cyanopyridine is a cyano substituted pyridine. 2-Cyanopyridine is a related compound of nicotine and is a component of tobacco smoke condensate.

Uses

It is employed as an important chemical intermediate for rimiterol hydrobromide and used as a bronchodilator. It is also used as intermediates of pharmaceutical and dye and pigment. It acts as a precursor of the respective amidate for protein modification via amidation.

Definition

ChEBI: A cyanopyridine carrying the cyano group at position 2.

Potential Exposure

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from heat or flame and separate fromoxidizing materials

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Incompatibilities

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .