ChemicalBook > CAS DataBase List > BeKm 1
BeKm 1
- Product Name
- BeKm 1
- CAS No.
- 524962-01-4
- Chemical Name
- BeKm 1
- CBNumber
- CB93343114
- Molecular Formula
- C174H261N51O52S6
- Formula Weight
- 4091.63464
- MOL File
- 524962-01-4.mol
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BeKm 1 Property
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
- Sequence
- Arg-Pro-Thr-Asp-Ile-Lys-Cys-Ser-Glu-Ser-Tyr-Gln-Cys-Phe-Pro-Val-Cys-Lys-Ser-Arg-Phe-Gly-Lys-Thr-Asn-Gly-Arg-Cys-Val-Asn-Gly-Phe-Cys-Asp-Cys-Phe (Disulfide bridge:Cys13-Cys33;Cys17-Cys35;Cys7-Cys28)
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BeKm 1 Chemical Properties,Usage,Production
Description
Potent and selective KV11.1 (hERG) channel blocker. Selective for KV11.1 over a panel of 14 other potassium channels. Dose-dependently prolongs QTc interval in isolated rabbit heart.
Uses
BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm-1 can be used for the research of heart disease[1].
References
[1] Milnes JT, et al. Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Lett. 2003;547(1-3):20-26. DOI:10.1016/s0014-5793(03)00662-8
BeKm 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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BeKm 1 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
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