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t-Boc-N-Amido-PEG4-Ms

Product Name
t-Boc-N-Amido-PEG4-Ms
CAS No.
1447797-72-9
Chemical Name
t-Boc-N-Amido-PEG4-Ms
Synonyms
Boc-NH-PEG4-Ms;t-Boc-N-Amido-PEG4-Ms;5,8,11,14-Tetraoxa-15-thia-2-azahexadecanoic acid, 1,1-dimethylethyl ester, 15,15-dioxide
CBNumber
CB93364016
Molecular Formula
C14H29NO8S
Formula Weight
371.45
MOL File
1447797-72-9.mol
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t-Boc-N-Amido-PEG4-Ms Property

Boiling point:
510.9±45.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
solubility 
Soluble in DCM
pka
12.22±0.46(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23282
Product name
t-Boc-N-Amido-PEG4-Ms
Purity
98%
Packaging
1g
Price
$680
Updated
2021/12/16
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t-Boc-N-Amido-PEG4-Ms Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG4-Ms is contains a t-Boc protected amine and a mesyl group. The t-Boc can be removed under acidic conditions. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains increase the water solubility properties of the compound.

Uses

Boc-NH-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG4-Ms Preparation Products And Raw materials

Raw materials

Preparation Products

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t-Boc-N-Amido-PEG4-Ms Suppliers

China 24 United States 2 Global 26
Hangzhou J&H Chemical Co., Ltd.
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View Lastest Price from t-Boc-N-Amido-PEG4-Ms manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Boc-NH-PEG4-Ms 1447797-72-9
Price
US $0.00/g
Min. Order
1g
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-25

1447797-72-9, t-Boc-N-Amido-PEG4-MsRelated Search:

t-Boc-N-Amido-PEG4-propargyl 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Boc-NH-PEG7-CH2CH2COOH 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester t-boc-N-amido-PEG5-azide t-Boc-N-amido-PEG5-acid Thiol-dPEG4-t-boc-N-amido t-Boc-N-amido-PEG4-(CH2)3CO2H t-Boc-N-amido-PEG5-MS t-Boc-N-amido-PEG5-NHS ester t-Boc-N-Amido-PEG7-propargyl t-Boc-N-Amido-PEG3-propargyl t-Boc-N-Amido-PEG6-Propargyl Boc-N-amido-PEG3-sulfonic acid t-Boc-N-Amido-PEG5-propargyl 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester t-Boc-N-Amido-PEG8-propargyl

  • t-Boc-N-Amido-PEG4-Ms
  • Boc-NH-PEG4-Ms
  • 5,8,11,14-Tetraoxa-15-thia-2-azahexadecanoic acid, 1,1-dimethylethyl ester, 15,15-dioxide
  • 1447797-72-9
  • 81447797-72-9
  • C14H29NO8S