ChemicalBook > CAS DataBase List > Ethyl 2-chloroacetoacetate

Ethyl 2-chloroacetoacetate

Product Name
Ethyl 2-chloroacetoacetate
CAS No.
609-15-4
Chemical Name
Ethyl 2-chloroacetoacetate
Synonyms
Ethyl 2-chloro-3-oxobutanoate;2-chloroacetoacetate;2-CHLORACETYLETHYL ACETATE;2-Chloro-3-oxobutanoic acid, ethyl ester;Butanoic acid, 2-chloro-3-oxo-, ethyl ester;A 21960;2-CL-ACE;AKOS BBS-00004302;Ethyl 2-chloroacetoa;2-Chloroacylacidester
CBNumber
CB9396009
Molecular Formula
C6H9ClO3
Formula Weight
164.59
MOL File
609-15-4.mol
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Ethyl 2-chloroacetoacetate Property

Melting point:
-80 °C
Boiling point:
107 °C/14 mmHg (lit.)
Density 
1.19 g/mL at 25 °C (lit.)
vapor pressure 
49.4-100Pa at 20℃
refractive index 
n20/D 1.441(lit.)
Flash point:
122 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
form 
Liquid
pka
7.92±0.46(Predicted)
color 
Clear yellow
Water Solubility 
17 g/L (20 ºC)
BRN 
774278
LogP
1.2 at 20℃ and pH1-7
Surface tension
69.4mN/m at 1g/L and 20℃
CAS DataBase Reference
609-15-4(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4)
EPA Substance Registry System
Ethyl 2-chloroacetoacetate (609-15-4)
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Safety

Hazard Codes 
C,Xn,F
Risk Statements 
10-22-34-52/53-36/37/38-36
Safety Statements 
16-26-36/37/39-45-61-37/39
RIDADR 
UN 2920 8/PG 2
WGK Germany 
2
F 
19
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
3.2
PackingGroup 
III
HS Code 
29183000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1218
Product name
Ethyl 2-Chloroacetoacetate
Purity
>95.0%(GC)
Packaging
25g
Price
$22
Updated
2025/07/31
TCI Chemical
Product number
C1218
Product name
Ethyl 2-Chloroacetoacetate
Purity
>95.0%(GC)
Packaging
500g
Price
$161
Updated
2025/07/31
Sigma-Aldrich
Product number
E16902
Product name
Ethyl 2-chloroacetoacetate
Purity
95%
Packaging
500g
Price
$87
Updated
2022/05/15
TRC
Product number
E903485
Product name
Ethyl2-Chloracetoacetate
Packaging
50g
Price
$120
Updated
2021/12/16
TRC
Product number
E903485
Product name
Ethyl2-Chloracetoacetate
Packaging
250g
Price
$275
Updated
2021/12/16
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Ethyl 2-chloroacetoacetate Chemical Properties,Usage,Production

Chemical Properties

clear bright yellow liquid

Uses

Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.

Biochem/physiol Actions

Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.

Synthesis

Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.

Ethyl 2-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Chloroacetyl Sulfuryl chloride Magnesium sulfate

Preparation Products

2,4-Dimethylthiazole-5-carboxylic acid 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 2-amino-4-methylthiazole-5-carboxylate 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 3,5-DIMETHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
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View Lastest Price from Ethyl 2-chloroacetoacetate manufacturers

Ningbo Banco Chemical Technology Co., Ltd.
Product
Ethyl 2-chloroacetoacetate 609-15-4
Price
US $30.00/kg
Min. Order
1kg
Purity
97.5%
Supply Ability
50Ton
Release date
2025-08-17
Hebei Chuanghai Biotechnology Co., Ltd
Product
Ethyl 2-chloroacetoacetate 609-15-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Shaanxi Didu New Materials Co. Ltd
Product
Ethyl 2-chloroacetoacetate 609-15-4
Price
US $17.00/kg
Min. Order
1kg
Purity
99.0% Min
Supply Ability
100 Tons
Release date
2025-03-28

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