Ethyl 2-chloroacetoacetate

Product Name: Ethyl 2-chloroacetoacetate
CAS No.: 609-15-4
Chemical Name: Ethyl 2-chloroacetoacetate
Synonyms: Ethyl 2-chloro-3-oxobutanoate;2-chloroacetoacetate;2-CHLORACETYLETHYL ACETATE;2-Chloro-3-oxobutanoic acid, ethyl ester;Butanoic acid, 2-chloro-3-oxo-, ethyl ester;A 21960;2-CL-ACE;AKOS BBS-00004302;Ethyl 2-chloroacetoa;2-Chloroacylacidester
CBNumber: CB9396009
Molecular Formula: C6H9ClO3
Formula Weight: 164.59
MOL File: 609-15-4.mol

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Ethyl 2-chloroacetoacetate Property

Melting point:: -80 °C
Boiling point:: 107 °C/14 mmHg (lit.)
Density: 1.19 g/mL at 25 °C (lit.)
vapor pressure: 49.4-100Pa at 20℃
refractive index: n20/D 1.441(lit.)
Flash point:: 122 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly)
form: Liquid
pka: 7.92±0.46(Predicted)
color: Clear yellow
Water Solubility: 17 g/L (20 ºC)
BRN: 774278
LogP: 1.2 at 20℃ and pH1-7
Surface tension: 69.4mN/m at 1g/L and 20℃
CAS DataBase Reference: 609-15-4(CAS DataBase Reference)
NIST Chemistry Reference: Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4)
EPA Substance Registry System: Ethyl 2-chloroacetoacetate (609-15-4)

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Safety

Hazard Codes: C,Xn,F
Risk Statements: 10-22-34-52/53-36/37/38-36
Safety Statements: 16-26-36/37/39-45-61-37/39
RIDADR: UN 2920 8/PG 2
WGK Germany: 2
F: 19
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 3.2
PackingGroup: III
HS Code: 29183000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1218
Product name: Ethyl 2-Chloroacetoacetate
Purity: >95.0%(GC)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: C1218
Product name: Ethyl 2-Chloroacetoacetate
Purity: >95.0%(GC)
Packaging: 500g
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: E16902
Product name: Ethyl 2-chloroacetoacetate
Purity: 95%
Packaging: 500g
Price: $87
Updated: 2022/05/15

TRC

Product number: E903485
Product name: Ethyl2-Chloracetoacetate
Packaging: 50g
Price: $120
Updated: 2021/12/16

TRC

Product number: E903485
Product name: Ethyl2-Chloracetoacetate
Packaging: 250g
Price: $275
Updated: 2021/12/16

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Ethyl 2-chloroacetoacetate Chemical Properties,Usage,Production

Chemical Properties

clear bright yellow liquid

Uses

Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.

Biochem/physiol Actions

Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.

Synthesis

Using ethyl acetoacetate and thionyl chloride as raw materials, the condensation reaction is carried out in the presence of a solvent. The dosage ratio of ethyl acetoacetate, thionyl chloride, and solvent is 1:1.37~2.75:2.31~4.62 by mass, the temperature of the condensation reaction is 75~95°C, and the reaction time is 5.5-9h. After stopping the reaction, evaporate most of the solvent and unreacted thionyl chloride under normal pressure, and then distill the remaining organic phase under reduced pressure to collect the 107-108°C/1.87kPa fraction to obtain Ethyl 2-chloroacetoacetate Products. The solvents used were n-heptane or, dichloroethane or toluene.

Ethyl 2-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Chloroacetyl Sulfuryl chloride Magnesium sulfate

Preparation Products

2,4-Dimethylthiazole-5-carboxylic acid 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE 4-METHYLOXAZOLE-5-CARBONYL CHLORIDE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE Ethyl 2-amino-4-methylthiazole-5-carboxylate 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 3,5-DIMETHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

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Ethyl 2-chloroacetoacetate Suppliers

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View Lastest Price from Ethyl 2-chloroacetoacetate manufacturers

Ningbo Banco Chemical Technology Co., Ltd.

Product: Ethyl 2-chloroacetoacetate 609-15-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 97.5%
Supply Ability: 50Ton
Release date: 2025-08-17

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 2-chloroacetoacetate 609-15-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-20

Shaanxi Didu New Materials Co. Ltd

Product: Ethyl 2-chloroacetoacetate 609-15-4
Price: US $17.00/kg
Min. Order: 1kg
Purity: 99.0% Min
Supply Ability: 100 Tons
Release date: 2025-03-28

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