ChemicalBook > CAS DataBase List > 5-Chloro-2-methoxybenzoic acid

5-Chloro-2-methoxybenzoic acid

Product Name: 5-Chloro-2-methoxybenzoic acid
CAS No.: 3438-16-2
Chemical Name: 5-Chloro-2-methoxybenzoic acid
Synonyms: Glyburide IMP;Compound Fr12564;RARECHEM AL BO 0576;5-CHLORO-O-ANISIC ACID;5-CHLORO-2-ANISIC ACID;Glyburide IMP Impurity;2-Carboxy-4-chloroanisole;5-Chloro-2-methoxybenzoic;5-Chloro-o-anisic acid,99%;5-chloro-2-methoxybenzoate
CBNumber: CB9424205
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 3438-16-2.mol

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5-Chloro-2-methoxybenzoic acid Property

Melting point:: 98-100 °C (lit.)
Boiling point:: 150-152C
Density: 1,259g/cm
refractive index: 1,544-1546
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Methanol
form: Crystalline Powder
pka: 3.72±0.10(Predicted)
color: White to off-white
InChI: InChI=1S/C8H7ClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey: HULDRQRKKXRXBI-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Cl)=CC=C1OC
LogP: 2.368 (est)
CAS DataBase Reference: 3438-16-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 292494
Product name: 5-Chloro-2-methoxybenzoic acid
Purity: 99%
Packaging: 25g
Price: $38.64
Updated: 2025/07/31

TCI Chemical

Product number: C1539
Product name: 5-Chloro-2-methoxybenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $93
Updated: 2025/07/31

TRC

Product number: C367910
Product name: 5-Chloro-2-methoxybenzoic Acid
Packaging: 25g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-5-Y2
Product name: 5-Chloro-2-methoxybenzoic acid
Purity: 97%
Packaging: 100g
Price: $141
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC36354
Product name: 5-Chloro-2-methoxybenzoic acid
Packaging: 500g
Price: $125
Updated: 2021/12/16

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5-Chloro-2-methoxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

5-Chloro-2-methoxybenzoic acid has been used in the synthesis of 5-chloro-2-methoxybenzoates of La(III), Ga(III) and Lu(III).

General Description

Complexes of 4-chloro-2-methoxybenzoic acid anion with Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺have been investigated.

Synthesis

33924-48-0

3438-16-2

General procedure for the synthesis of 5-chloro-2-methoxybenzoic acid from methyl 5-chloro-2-methoxybenzoate: to a 1 M aqueous sodium hydroxide solution (60 mL, 0.06 mol) was added a solution of methyl 5-chloro-2-methoxybenzoate (2.0 g, 0.01 mol) [Alfa Aesar] in ethanol (60 mL). The reaction mixture was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until completion of the reaction. Subsequently, the reaction mixture was concentrated under reduced pressure to remove ethanol and the residue was separated by extraction with ethyl acetate. The aqueous phase was cooled in an ice bath and the pH was adjusted with concentrated aqueous hydrochloric acid to 2. After continued stirring in an ice bath for 1 h, the precipitated solid was collected by filtration, washed with water and dried in air to afford 1.4 g (74.9% yield) of the target product, 5-chloro-2-methoxybenzoic acid, as a white solid. Mass spectrum (MS): m/z 185.1 (MH+). 1H NMR (500 MHz, DMSO-d6): δ 3.818 (s, 3H), 7.162 (d, 1H), 7.551 (dd, 1H), 7.607 (d, 1H).

References

[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6819 - 6829
[2] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 98-99
[3] Journal of the American Chemical Society, 1988, vol. 110, p. 7178
[4] Patent: US4895860, 1990, A

5-Chloro-2-methoxybenzoic acid Preparation Products And Raw materials

Raw materials

5-Chloro-2-hydroxybenzoic acid Dimethyl sulfate

Preparation Products

4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE 5-CHLORO-2-METHOXYBENZOYL CHLORIDE 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

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View Lastest Price from 5-Chloro-2-methoxybenzoic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Chloro-2-methoxybenzoic acid 3438-16-2
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-25

Career Henan Chemical Co

Product: 5-Chloro-2-methoxybenzoic acid 3438-16-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

3438-16-2, 5-Chloro-2-methoxybenzoic acidRelated Search:

EPA Anisole 3-Chloroperoxybenzoic acid (Trifluoromethoxy)benzene p-Anisidine 4-Methoxybenzoic acid 4-Methoxybenzylchloride 5-Chloro-2-methylbenzoic acid 3-Methoxybenzoic acid 2-Methoxybenzoic acid 2,6-Dimethoxybenzoic acid 3,4-Dimethoxybenzoic acid 4-(Chloromethyl)benzoic acid Ascoric Acid Difluorochloromethane 3-CHLORO-2,6-DIMETHOXY-5-NITROBENZOIC ACID N-ACETYL-4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, METHYL ESTER,4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID METHYL ESTER 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID

2-Carboxy-4-chloroanisole

5-Chloro-N-(2-phenylethyl)-2-MethoxybenzaMide

Glyburide IMP

RARECHEM AL BO 0576

5-Chloro-o-anisic acid,99%

2-METHOXY-5-CHLOROBENZOIC ACID

5-CHLORO-2-METHOXYBENZOIC ACID

5-CHLORO-2-ANISIC ACID

5-CHLORO-O-ANISIC ACID

5-Chloro-2-methoxybenzoicacid,98%

5-Chloro-2-methoxybenzoicacid,99%

5-chloro-2-methoxybenzoic acid (intermediate of glibenclamide)

5-Chloro-2-methoxybenzoic acid 97%

5-CHLORO-2-METHOXYBENZOIC ACID / 5-CHLORO-O-ANISIC ACID

5-chloro-2-methoxybenzoate

5-Chloro-2-methoxybenzoicAcid&gt

Benzoic acid, 5-chloro-2-methoxy-

5-Chloro-2-methoxybenzoic acid (Glibenclamide Impurity)

5-Chloro-2-methoxybenzoic

Compound Fr12564

Glibenclamide impurity 9(5-Chloro-2-methoxybenzoic acid)

Glyburide IMP Impurity

3438-16-2

5438-16-2

Organic Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Building Blocks

Carbonyl Compounds

Carboxylic Acids

API Intermediate

FINE Chemical & INTERMEDIATES

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Organic acids

(intermediate of glibenclamide)

Miscellaneous

Acids & Esters

Anisoles, Alkyloxy Compounds & Phenylacetates

Chlorine Compounds