5-Chloro-2-methoxybenzoic acid
- Product Name
- 5-Chloro-2-methoxybenzoic acid
- CAS No.
- 3438-16-2
- Chemical Name
- 5-Chloro-2-methoxybenzoic acid
- Synonyms
- Glyburide IMP;Compound Fr12564;RARECHEM AL BO 0576;5-CHLORO-O-ANISIC ACID;5-CHLORO-2-ANISIC ACID;Glyburide IMP Impurity;2-Carboxy-4-chloroanisole;5-Chloro-2-methoxybenzoic;5-Chloro-o-anisic acid,99%;5-chloro-2-methoxybenzoate
- CBNumber
- CB9424205
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 3438-16-2.mol
5-Chloro-2-methoxybenzoic acid Property
- Melting point:
- 98-100 °C (lit.)
- Boiling point:
- 150-152C
- Density
- 1,259g/cm
- refractive index
- 1,544-1546
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Crystalline Powder
- pka
- 3.72±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C8H7ClO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)
- InChIKey
- HULDRQRKKXRXBI-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(Cl)=CC=C1OC
- LogP
- 2.368 (est)
- CAS DataBase Reference
- 3438-16-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 292494
- Product name
- 5-Chloro-2-methoxybenzoic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $38.64
- Updated
- 2025/07/31
- Product number
- C1539
- Product name
- 5-Chloro-2-methoxybenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $93
- Updated
- 2025/07/31
- Product number
- C367910
- Product name
- 5-Chloro-2-methoxybenzoic Acid
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 2621-5-Y2
- Product name
- 5-Chloro-2-methoxybenzoic acid
- Purity
- 97%
- Packaging
- 100g
- Price
- $141
- Updated
- 2021/12/16
- Product number
- FC36354
- Product name
- 5-Chloro-2-methoxybenzoic acid
- Packaging
- 500g
- Price
- $125
- Updated
- 2021/12/16
5-Chloro-2-methoxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystalline powder
Uses
5-Chloro-2-methoxybenzoic acid has been used in the synthesis of 5-chloro-2-methoxybenzoates of La(III), Ga(III) and Lu(III).
General Description
Complexes of 4-chloro-2-methoxybenzoic acid anion with Mn2+, Co2+, Ni2+, Cu2+ and Zn2+ have been investigated.
Synthesis
33924-48-0
3438-16-2
General procedure for the synthesis of 5-chloro-2-methoxybenzoic acid from methyl 5-chloro-2-methoxybenzoate: to a 1 M aqueous sodium hydroxide solution (60 mL, 0.06 mol) was added a solution of methyl 5-chloro-2-methoxybenzoate (2.0 g, 0.01 mol) [Alfa Aesar] in ethanol (60 mL). The reaction mixture was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until completion of the reaction. Subsequently, the reaction mixture was concentrated under reduced pressure to remove ethanol and the residue was separated by extraction with ethyl acetate. The aqueous phase was cooled in an ice bath and the pH was adjusted with concentrated aqueous hydrochloric acid to 2. After continued stirring in an ice bath for 1 h, the precipitated solid was collected by filtration, washed with water and dried in air to afford 1.4 g (74.9% yield) of the target product, 5-chloro-2-methoxybenzoic acid, as a white solid. Mass spectrum (MS): m/z 185.1 (MH+). 1H NMR (500 MHz, DMSO-d6): δ 3.818 (s, 3H), 7.162 (d, 1H), 7.551 (dd, 1H), 7.607 (d, 1H).
References
[1] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 21, p. 6819 - 6829
[2] Patent: WO2014/165816, 2014, A1. Location in patent: Page/Page column 98-99
[3] Journal of the American Chemical Society, 1988, vol. 110, p. 7178
[4] Patent: US4895860, 1990, A
5-Chloro-2-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-2-methoxybenzoic acid Suppliers
- Tel
- --
- Fax
- --
- y.barysheva@ukrorgsynth.com
- Country
- Ukraine
- ProdList
- 6230
- Advantage
- 38
- Tel
- --
- Fax
- --
- Sales@casorganic.com
- Country
- Ukraine
- ProdList
- 5026
- Advantage
- 34
View Lastest Price from 5-Chloro-2-methoxybenzoic acid manufacturers
- Product
- 5-Chloro-2-methoxybenzoic acid 3438-16-2
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-25
- Product
- 5-Chloro-2-methoxybenzoic acid 3438-16-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20