SB216763

Product Name: SB216763
CAS No.: 280744-09-4
Chemical Name: SB216763
Synonyms: CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);SB 216763, 10 mM in DMSO;SB 216763, GSK3 inhibitor;3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem
CBNumber: CB9493416
Molecular Formula: C19H12Cl2N2O2
Formula Weight: 371.22
MOL File: 280744-09-4.mol

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SB216763 Property

Melting point:: 287-288.6 °C(lit.)
Boiling point:: 598.1±50.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 20 mg/mL, soluble
form: Orange solid
pka: 7.27±0.60(Predicted)
color: orange
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S3442
Product name: SB 216763
Purity: >98% (HPLC)
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Sigma-Aldrich

Product number: S3442
Product name: SB 216763
Purity: >98% (HPLC)
Packaging: 25mg
Price: $708
Updated: 2024/03/01

TCI Chemical

Product number: B5716
Product name: SB 216763
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $118
Updated: 2024/03/01

TCI Chemical

Product number: B5716
Product name: SB 216763
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $352
Updated: 2024/03/01

Cayman Chemical

Product number: 10010246
Product name: SB 216763
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

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SB216763 Chemical Properties,Usage,Production

Description

SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.

Uses

SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.

Uses

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Definition

ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Biochem/physiol Actions

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

storage

Room temperature

References

1) Coghlan et al. (2000), Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription; Chem. Biol., 7 793 2) Gurrieri et al. (2010), 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis; J. Pharmacol. Exp. Ther., 332 785 3) Cross et al. (2001), Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death; J. Neurochem., 77 94 4) Kirby et al. (2012), Glycogen synthase kinase 3 (GSK3) inhibitor , SB-216763, promotes pluripotency in mouse embryonic stem cells; PLoS One, 7 e39329

SB216763 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB216763 Suppliers

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View Lastest Price from SB216763 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: SB216763 280744-09-4
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: SB216763 280744-09-4
Price: US $19.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

Career Henan Chemical Co

Product: SB216763 280744-09-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

280744-09-4, SB216763Related Search:

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CS-332

GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem

SB 216763

3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE

3-(2,4-Dichlorophenyl)-4-...

3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

SB-216763(SB 216763)

GSK-3 Inhibitor IV, SB-216763

3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione

1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-

SB216763 USP/EP/BP

3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide

SB 216763, GSK3 inhibitor

SB 216763, 10 mM in DMSO

280744-09-4

C19H12Cl2N2O2

C19H12N2O2Cl2

C19Cl2H12N2O2

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Glycogen Synthase Kinase 3 (GSK3)

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Inhibitors

Akt

mTOR

PI3K

Protein Kinase

Signalling