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PROTAC FLT-3 degrader 1

Product Name
PROTAC FLT-3 degrader 1
CAS No.
2230826-81-8
Chemical Name
PROTAC FLT-3 degrader 1
Synonyms
FLT-3 degrader 1;PROTAC FLT-3 degrader 1;PROTACFLT-3degrader1/FLT3PROTAC;(2S,4R)-1-[(2S)-2-{3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,?]dodeca-1(8),3,5,9,11-pentaen-10-yl]oxy}ethoxy)ethoxy]propanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber
CB95540575
Molecular Formula
C52H61N9O9S2
Formula Weight
1020.23
MOL File
2230826-81-8.mol
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PROTAC FLT-3 degrader 1 Property

Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 150 mg/mL (147.03 mM; Need ultrasonic)
form 
Solid
pka
12.59±0.70(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0082105
Product name
PROTACFLT-3degrader1
Purity
98.70%
Packaging
1mg
Price
$780
Updated
2021/12/16
ChemScene
Product number
CS-0082105
Product name
PROTACFLT-3degrader1
Purity
98.70%
Packaging
5mg
Price
$2000
Updated
2021/12/16
ChemScene
Product number
CS-0082105
Product name
PROTACFLT-3degrader1
Purity
98.70%
Packaging
10mg
Price
$3200
Updated
2021/12/16
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PROTAC FLT-3 degrader 1 Chemical Properties,Usage,Production

Biological Activity

PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].

References

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

PROTAC FLT-3 degrader 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC FLT-3 degrader 1 Suppliers

China 10 United States 1 Global 11
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58

2230826-81-8, PROTAC FLT-3 degrader 1Related Search:

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  • PROTAC FLT-3 degrader 1
  • PROTACFLT-3degrader1/FLT3PROTAC
  • FLT-3 degrader 1
  • (2S,4R)-1-[(2S)-2-{3-[2-(2-{[4-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,?]dodeca-1(8),3,5,9,11-pentaen-10-yl]oxy}ethoxy)ethoxy]propanamido}-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
  • 2230826-81-8