ChemicalBook > CAS DataBase List > 1-Boc-3-hydroxymethyl-piperazine

1-Boc-3-hydroxymethyl-piperazine

Product Name
1-Boc-3-hydroxymethyl-piperazine
CAS No.
301673-16-5
Chemical Name
1-Boc-3-hydroxymethyl-piperazine
Synonyms
tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;1-Boc-3-hydroxymethyl-piperazine;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE;4-N-Bo;1-BOC-3-hydroxymethypiperazine;N-BOC-3-HYDROXYMETHYLPIPERAZINE;4-Boc-2-hydroxymethyl-piperazine;1-N-BOC-3-HYDROXYMETHYLPIPERAZINE;1-N-Boc-3-hydroxymethylpiperazine 98%;4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
CBNumber
CB9726620
Molecular Formula
C10H20N2O3
Formula Weight
216.28
MOL File
301673-16-5.mol
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1-Boc-3-hydroxymethyl-piperazine Property

Melting point:
93.0 to 97.0 °C
Boiling point:
322.9±22.0 °C(Predicted)
Density 
1.085±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
14.97±0.10(Predicted)
color 
White to Almost white
CAS DataBase Reference
301673-16-5(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2939800000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4716
Product name
1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
200mg
Price
$147
Updated
2024/03/01
TCI Chemical
Product number
B4716
Product name
1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$635
Updated
2023/06/20
TRC
Product number
B656643
Product name
4-N-Boc-2-HydroxymethylpiperazineHydrochloride
Packaging
100mg
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-D0661
Product name
1-Boc-3-hydroxymethyl-piperazine
Purity
≥97.0%
Packaging
1g
Price
$29
Updated
2021/12/16
Matrix Scientific
Product number
073454
Product name
1-Boc-(3-Hydroxymethyl)piperazine
Purity
95+%
Packaging
1g
Price
$49
Updated
2021/12/16
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1-Boc-3-hydroxymethyl-piperazine Chemical Properties,Usage,Production

Uses

1-Boc-3-Hydroxymethylpiperazine is an organic compound commonly used as an organic synthesis intermediate and pharmaceutical intermediate.

Synthesis

143540-05-0

301673-16-5

General procedure for the synthesis of 1-BOC-3-hydroxymethylpiperazine from 1,4-bis(Boc)-2-piperazinemethanol: To a solution of di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate (4.00 g, 12.6 mmol) in ethanol (110 ml) was added sodium hydroxide (1.99 g, 49.8 mmol), and the mixture was heated under reflux conditions for 16 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was poured into water and the mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the target product 1-BOC-3-hydroxymethylpiperazine (2.71 g, 99.6% yield) as a solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 1.46 (9H, s), 2.12 (1H, br s), 2.64-3.01 (6H, br s), 3.47-3.53 (1H, m), 3.62-3.67 (1H, m), 3.89 (2H, br s).

References

[1] Patent: US2009/318412, 2009, A1. Location in patent: Page/Page column 34-35
[2] Patent: EP1338595, 2003, A2

1-Boc-3-hydroxymethyl-piperazine Preparation Products And Raw materials

Raw materials

Methanesulfonic anhydride Ethanol Potassium hydroxide 2-Pyrazinecarboxylic acid Calcium chloride Di-tert-butyl dicarbonate Potassium carbonate N,N-Diisopropylethylamine Sodium borohydride Lithium hydroxide Palladium 1,4-Dioxane Tetrahydrofuran 1,2-Dichloroethane Lithium Aluminum Hydride N,N-Dimethylacrylamide Dichloromethane Iodomethane PIPERAZINE-2-CARBOXYLIC ACID

Preparation Products

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View Lastest Price from 1-Boc-3-hydroxymethyl-piperazine manufacturers

Career Henan Chemical Co
Product
3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 301673-16-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08
Career Henan Chemical Co
Product
3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 301673-16-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg，5kg，100kg
Release date
2019-07-10

301673-16-5, 1-Boc-3-hydroxymethyl-piperazineRelated Search:

1-Boc-3-hydroxymethylpyrrolidine tert-butyl 3-(cyanoMethyl)piperidine-1-carboxylate 1-Boc-3-(Aminomethyl)azetidine (R)-1-BOC-3-(Hydroxymethyl)piperazine (S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID 1,4-BIS(N-BOC)PIPERAZINE-2-CARBOXYLIC ACID N-4-BOC-N-1-CBZ-2-PIPERAZINE CARBOXYLIC ACID 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-4-Boc-2-piperazinecarboxylic acid METHYL N-4-BOC-N-1-CBZ-2-PIPERAZINECARBOXYLATE (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 4-Boc-1-Fmoc-2-piperazinecarboxylic acid METHYL 4-BOC-PIPERAZINE-2-CARBOXYLATE (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID (R)-1-N-Boc-2-(hydroxymethyl)piperazine (S)-1-Boc-2-Hydroxymethyl-piperazine 1-N-Boc-2-(hydroxymethyl)piperazine

  • 2-(HYDROXYMETHYL)-4-N-TERT-BUTOXYCARBONYL-PIPERAZINE
  • 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE
  • 3-(HYDROXYMETHYL)-1-PIPERAZINE CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
  • 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate
  • REF DUPL: 4-N-Boc-2-hydroxymethylpiperazine
  • 4-Boc-2-hydroxymethyl-piperazine
  • 1-BOC-3-hydroxymethypiperazine
  • 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
  • 3-Hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester ,97%
  • 4-N-Bo
  • 3-(Hydroxymethyl)piperazine, N1-BOC protected
  • tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate, 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
  • 4-N-BOC-2-HYDROXYMETHYLPIPERAZINE -HCl
  • 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
  • 1-(<i>tert</i>-Butoxycarbonyl)-3-(hydroxymethyl)piperazine
  • 3-(Hydroxymethyl)-1-piperazinecarboxylic acid tert-butyl ester
  • 1-Boc-3-hydroxymethyl-piperazine
  • N-BOC-3-HYDROXYMETHYLPIPERAZINE
  • 1-N-BOC-3-HYDROXYMETHYLPIPERAZINE
  • (RS)-1-Boc-3-(hydroxyMethyl)-piperazine
  • 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID
  • tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylat
  • 3-(Hydroxymethyl)piperazine, N1-BOC protected 97%
  • 1-N-Boc-3-hydroxymethylpiperazine 98%
  • 4-N-Boc-2-Hydroxymethylpiperazine Hydrochloride
  • 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester (9CI, ACI)
  • 3-(hydroxymethyl)-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI)
  • 301673-16-5
  • pharmacetical
  • Piperaizine