3-Cyanopyridine Property

Melting point:

48-52 °C(lit.)

Boiling point:

201 °C(lit.)

Density 

1.159

refractive index 

1.5242 (estimate)

Flash point:

184 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

140g/l

form 

Crystalline Mass, Crystals or Chunks

pka

pK1:1.45(+1) (25°C)

color 

Colorless or white to yellow

Water Solubility 

140 g/L (20 ºC)

BRN 

107711

Exposure limits

NIOSH: IDLH 25 mg/m3

Stability:

Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases.

InChIKey

GZPHSAQLYPIAIN-UHFFFAOYSA-N

CAS DataBase Reference

100-54-9(CAS DataBase Reference)

NIST Chemistry Reference

3-Pyridinecarbonitrile(100-54-9)

EPA Substance Registry System

3-Pyridinecarbonitrile (100-54-9)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

22-24/25-36/37/39-26

WGK Germany 

3

RTECS 

QT3030000

TSCA 

Yes

HS Code 

29333999

Hazardous Substances Data

100-54-9(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-Cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

white to beige solid

Chemical Properties

The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.

Uses

3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol.

Definition

ChEBI: A nitrile that is pyridine substituted by a cyano group at position 3.

Synthesis Reference(s)

Tetrahedron Letters, 29, p. 2155, 1988 DOI: 10.1016/S0040-4039(00)86697-6

Potential Exposure

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Purification Methods

It is recrystallised to constant melting point from o-xylene/hexane. [Beilstein 22/2 V 115.]

Incompatibilities

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .