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Terpenes

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Terpenes is the generic term summarizing all kinds of isoprene polymers and their derivatives with its general formula of (C5H8) n. Terpene is a class of compound that is ubiquitous in the plant kingdom, but exist in very few amount in the animal kingdom. Except in the form of terpene hydrocarbons, there are a large number of terpenes forming various kinds of oxygenated derivatives including alcohols, aldehydes, ketones, carboxylic acids, esters and glycoside forms. Secondly there are also nitrogen-containing derivatives as well as a minority of sulfur-containing derivatives presented. Based on the number of the isoprene units contained inside the molecule, the terpenes can be divided into: monoterpene, sesquiterpenoid, diterpene, sesquiterpene, triterpenoids, tetraterpene and polyterpene.

For some compound which originated from the synthesis of isoprene, but has the number of carbon atoms in the molecule be not an integer multiple of 5, they are called terpenoid. In the life activities, terpenoids compound, especially inside the plants, have important functions, for example gibberellin, abscisic acid and insect juvenile hormone are important hormones, carotenoids and chlorophyll are important photosynthetic pigments; plastoquinone and quinone are respectively important electronic chain delivery body in photosynthesis and respiration chain; sterols are the component of the biological membrane.

Monoterpene and sesquiterpene are the major component of volatile oil. Diterpene is the major substance forming the resin; triterpenoid is an important material forming plant saponins and resins, tetraterpene mainly include some fat-soluble pigments widely distributed in the plants. In nature, terpenoids is widely distributed, some of which have physiological activity. For example, ascaridole and santonin have roundworm expelling effect; artemisinin has antimalarial effect while andrographolidume has antibacterial effect.

The following describes some of the chemical reactions associated with terpenes. This is significant for determination of the chemical structure of terpene component.

(1) Oxidation reaction
Different oxidants, in different situations, can oxidize the different groups contained in terpene component to produce different products. For example, chromic acid can oxidize the carbon methyl group and gem-dimethyl carbon to produce acetic acid; the oxidation reaction of ozone is a valuable double bond cleavage reaction and can determine the position of double bond in the structure of the terpene composition. Lead tetraacetate is also oxidation agents of double-bond and has been widely used in chemical research of the terpene ingredients.

(2) The dehydrogenation
Dehydrogenation reaction can be considered as a kind of oxidation reactions and is a kind of valuable reaction for the study the chemical structure of terpenes particularly cyclic terpene. It refers to that the terpene component is heated (200 ℃ ~ 300 ℃) together with sulfur or selenium under an inert atmosphere, the carbon skeleton of the cyclic terpene is dehydrogenated into aromatic derivatives with sometimes the ring being cleaved and sometimes cyclization occurring simultaneously.

(3) Addition reaction
The double bonds in the terpene components can react with hydrogen halide acids such as hydroiodic acid or hydrogen chloride in glacial acetic acid solution to generate crystalline-shaped addition product. It can also absorb bromine (diethyl ether or glacial acetic acid - ethanol solution) to generate bromide with certain physicochemical properties. If mixing the glacial acetic acid and sodium nitrite for shaking, nitrous oxide or pseudo-nitrous oxide will be generate and will exhibit visible special colors.
If the unsaturated terpene component was added with amyl nitrite and concentrated hydrochloric acid for mixing with shaking and keep it cool, then add a small amount of ethanol or glacial acetic acid, there will be chlorinated nitroso derivative of terpenes generated with special colors as well. Such nitroso derivatives (including nitrous oxides and chlorinated nitroso derivative) mostly exhibit blue or blue-green color. They are easily polymerized to form a colorless di-polymer, but when the di-polymer is heated to a molten state or when made into a solution, it can also be converted into a blue or blue-green single-molecule compound.
Nitroso chlorinated derivatives can condense with primary or secondary amines (commonly piperidine) to generate nitroso amines with most of them having complete crystal shape and  certain physical and chemical constants available for the identification of unsaturated terpene components. If the terpene component molecules contain conjugated double bonds, then it will form crystalline addition product with maleic anhydride through Diels-Alder reaction which can be used to prove the presence of conjugated double bonds.

(4) Wagner-Meerweein rearrangement;
Terpene molecules, sometimes through the effect of agents (such as acid, etc.), the carbon skeleton can be changed or the functional groups in the molecule can be transferred in the molecule. Especially during the elimination reaction, addition reaction or a nucleophilic substitution reaction of bicyclic terpene compound, there is often Wagner-Meerweein rearrangement happening.

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Structure:
Chemical Name:
PICRASIN-B
CAS:
26121-56-2
MF:
C21H28O6
Structure:
Chemical Name:
1-Naphthalenepropanol,.alp
CAS:
1438-62-6
MF:
C20H34O
Structure:
Chemical Name:
POMOLIC ACID
CAS:
13849-91-7
MF:
C30H48O4
Structure:
Chemical Name:
lupeol caffeate
CAS:
103917-26-6
MF:
C39H58O4
Structure:
Chemical Name:
rubelloside B
CAS:
167875-39-0
MF:
C42H66O14
Structure:
Chemical Name:
ent-11,16-Epoxy-15-hydroxykauran-19-oic acid
CAS:
77658-46-9
MF:
C20H30O4
Structure:
Chemical Name:
Epifriedelal acetate
CAS:
2259-07-6
MF:
C32H54O2
Structure:
Chemical Name:
Forskolin J
CAS:
81873-08-7
MF:
C24H36O8
Structure:
Chemical Name:
Coronalolide
CAS:
268214-51-3
MF:
C30H42O5
Structure:
Chemical Name:
(4R)-3β,21β-Dihydroxy-C(14a)-homo-27-norgammacer-14-en-23-oic acid
CAS:
53755-77-4
MF:
C30H48O4
Structure:
Chemical Name:
Lophanthoidin F
CAS:
120462-46-6
MF:
C24H34O7
Structure:
Chemical Name:
Methyl lycernuate A
CAS:
56218-46-3
MF:
C31H50O4
Structure:
Chemical Name:
Piscidil A
CAS:
100198-09-2
MF:
C30H50O4
Structure:
Chemical Name:
p-Menthane-1,3,8-triol
CAS:
155348-06-4
MF:
C10H20O3
Structure:
Chemical Name:
Quivin
CAS:
107870-05-3
MF:
C36H56O9
Structure:
Chemical Name:
Sculponeatin N
CAS:
1169805-98-4
MF:
C25H40O4
Structure:
Chemical Name:
Semialactone
CAS:
366450-46-6
MF:
C30H44O4
Structure:
Chemical Name:
8(14),15-Isopimaradiene-3,18-diol
CAS:
59219-64-6
MF:
C20H32O2
Structure:
Chemical Name:
Myriceric acid C
CAS:
162059-94-1
MF:
C48H60O10
Structure:
Chemical Name:
Pepluanin A
CAS:
670257-89-3
MF:
C43H51NO15
Structure:
Chemical Name:
Rubifolic acid
CAS:
80489-65-2
MF:
C30H48O4
Structure:
Chemical Name:
Scutebarbatine B
CAS:
905929-95-5
MF:
C33H35NO7
Structure:
Chemical Name:
Simiarel acetate
CAS:
4965-99-5
MF:
C32H52O2
Structure:
Chemical Name:
13-Epijhanol
CAS:
133005-15-9
MF:
C20H34O2
Structure:
Chemical Name:
2',3'-Dehydrosalannol
CAS:
97411-50-2
MF:
C32H42O8
Structure:
Chemical Name:
19-hydroxybaccatin III
CAS:
78432-78-7
MF:
C31H38O12
Structure:
Chemical Name:
cycloleucalenol
CAS:
469-39-6
MF:
C30H50O
Structure:
Chemical Name:
(20R,24S)-20,24-Epoxy-25-hydroxydammaran-3-one
CAS:
22549-21-9
MF:
C30H50O3
Structure:
Chemical Name:
(4S)-C(14a)-Homo-27-norgammacer-14-ene-3α,21β,24-triol
CAS:
13956-51-9
MF:
C30H50O3
Structure:
Chemical Name:
20-Hydroxy-4,8,14-trimethyl-4-methylene-18-nor-3,4-seco-5β-cholane-3,24-dioic acid γ-lactone
CAS:
2202-01-9
MF:
C27H42O4
Structure:
Chemical Name:
1,4-Epoxy-p-menthane-2,3-diol
CAS:
36150-04-6
MF:
C10H20O3
Structure:
Chemical Name:
Lup-20(29)-ene-1β,3α-diol
CAS:
6610-56-6
MF:
C30H50O2
Structure:
Chemical Name:
C(14a)-Homo-27-norgammacer-14-ene-3β,21β-diol 3-acetate
CAS:
1260-05-5
MF:
C32H52O3
Structure:
Chemical Name:
(S)-2,3-Bis(hydroxymethyl)-1-(2-hydroxyethyl)-1-cyclopentene
CAS:
126594-64-7
MF:
C9H16O3
Structure:
Chemical Name:
(2E,6E)-8-Hydroxy-2,6-dimethyl-2,6-octadienoic acid
CAS:
26187-80-4
MF:
C10H16O3
Structure:
Chemical Name:
Isosalvipuberulin
CAS:
115321-32-9
MF:
C20H14O5
Structure:
Chemical Name:
TRIPTOQUINONEB
CAS:
142937-50-6
MF:
C20H26O4
Structure:
Chemical Name:
12-Acetoxyabietic acid
CAS:
83905-81-1
MF:
C22H32O4
Structure:
Chemical Name:
12-Ursene-3,16,22-triol
CAS:
1242085-06-8
MF:
C30H50O3
Structure:
Chemical Name:
15,16-Di-O-acetyldarutoside
CAS:
1188282-02-1
MF:
C30H48O10
Structure:
Chemical Name:
15-Isopimarene-8,18-diol
CAS:
73002-86-5
MF:
C20H34O2
Structure:
Chemical Name:
19-[(beta-D-glucopyrasyl)oxy]- 19-oxo-ent-labda-8(17),13-dien-16,15-olide
CAS:
919120-78-8
MF:
C26H38O9
Structure:
Chemical Name:
2,3,24-Trihydroxyolean-12-en-28-oic acid
CAS:
150821-16-2
MF:
C30H48O5
Structure:
Chemical Name:
27-p-Coumaroyloxyursolic acid
CAS:
73584-67-5
MF:
C39H54O6
Structure:
Chemical Name:
3-Acetoxy-8(17),13E-labdadien-15-oic acid
CAS:
63399-37-1
MF:
C22H34O4
Structure:
Chemical Name:
Biondinin C
CAS:
55511-08-5
MF:
C19H24O3
Structure:
Chemical Name:
Cabraleadiol
CAS:
67253-01-4
MF:
C30H52O3
Structure:
Chemical Name:
Ceathic acid acetate
CAS:
119533-63-0
MF:
C32H48O6
Structure:
Chemical Name:
Chinensine B
CAS:
849245-34-7
MF:
C20H28O3
Structure:
Chemical Name:
Yunnancoronarin A
CAS:
162762-93-8
MF:
C20H28O2
Structure:
Chemical Name:
2,5,9,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxyjatropha-6(17),11E-diene
CAS:
210108-88-6
MF:
C39H52O14
Structure:
Chemical Name:
23-HydroxyMangiferonic acid
CAS:
232266-08-9
MF:
C30H46O4
Structure:
Chemical Name:
28-Hydroxy-3-oxoolean-12-en-29-oic acid
CAS:
381691-22-1
MF:
C30H46O4
Structure:
Chemical Name:
Labd-13-ene-8,15-diol
CAS:
10267-31-9
MF:
C20H36O2
Structure:
Chemical Name:
Ent-16S,17-dihydroxyatisan-3-one
CAS:
112523-91-8
MF:
C20H32O3
Structure:
Chemical Name:
6-Hydroxy-2,6-dimethyl-2,7-octadieic acid
CAS:
28420-25-9
MF:
C10H16O3
Structure:
Chemical Name:
7,15-Dihydroxy-8(14)-podocarpen-13-one
CAS:
262355-96-4
MF:
C17H26O3
Structure:
Chemical Name:
9-Hydroxydarutigel
CAS:
1188282-00-9
MF:
C20H34O4
Structure:
Chemical Name:
Alstonic acid A
CAS:
1159579-44-8
MF:
C30H48O3
Structure:
Chemical Name:
Bulleyanin
CAS:
123043-54-9
MF:
C28H38O10
Structure:
Chemical Name:
Cabraleahydroxylactone acetate
CAS:
35833-70-6
MF:
C29H46O4
Structure:
Chemical Name:
Coronarin D methyl ether
CAS:
157528-81-9
MF:
C21H32O3
Structure:
Chemical Name:
Forrestin A
CAS:
152175-76-3
MF:
C30H42O11
Structure:
Chemical Name:
Fupenzic acid
CAS:
119725-20-1
MF:
C30H44O5
Structure:
Chemical Name:
Scutebata F
CAS:
1207181-62-1
MF:
C30H37NO9
Structure:
Chemical Name:
Villosin C
CAS:
160927-81-1
MF:
C20H24O6
Structure:
Chemical Name:
3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid
CAS:
131984-82-2
MF:
C30H46O6
Structure:
Chemical Name:
15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene
CAS:
61597-55-5
MF:
C20H30O2
Structure:
Chemical Name:
2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(17),11E-diene
CAS:
210108-89-7
MF:
C41H49NO14
Structure:
Chemical Name:
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid
CAS:
870456-88-5
MF:
C30H44O4
Structure:
Chemical Name:
3-Oxotirucalla-7,24-dien-21-oic acid
CAS:
82464-35-5
MF:
C30H46O3
Structure:
Chemical Name:
Cabralealactone
CAS:
19865-87-3
MF:
C27H42O3
Structure:
Chemical Name:
Dulcioic acid
CAS:
78516-69-5
MF:
C30H48O3
Structure:
Chemical Name:
Quinovic acid 3-O-(3',4'-O-isopropylidene)-beta-D-fucopyranoside
CAS:
182132-59-8
MF:
C39H60O9
Structure:
Chemical Name:
Triptocallic acid D
CAS:
201534-09-0
MF:
C30H48O4
Structure:
Chemical Name:
(-)-6beta-Hydroxy-5beta,8beta,9beta,10alpha-cleroda-3,13-dien-16,15-olid-18-oic acid
CAS:
771493-42-6
MF:
C20H28O5
Structure:
Chemical Name:
(9aS)-7,8,9,9a-Tetrahydro-9a-hydroxy-6-methyl-9-(1-methylethenyl)-2-(1-methylethyl)-1H-phenalen-1-one
CAS:
453518-30-4
MF:
C20H24O2
Structure:
Chemical Name:
Acantrifoic acid A
CAS:
654663-85-1
MF:
C32H48O7
Structure:
Chemical Name:
Isovouacapenol C
CAS:
455255-15-9
MF:
C27H34O5
Structure:
Chemical Name:
Verbenacine
CAS:
717901-03-6
MF:
C20H30O3
Structure:
Chemical Name:
Borapetoside D
CAS:
151200-48-5
MF:
C33H46O16
Structure:
Chemical Name:
ent-Atisane-3β,16α,17-triol
CAS:
115783-44-3
MF:
C20H34O3
Structure:
Chemical Name:
12-O-Methylcarnosic acid
CAS:
62201-71-2
MF:
C21H30O4
Structure:
Chemical Name:
3,4-seco-Olean-12-en-4-ol-3,28-dioic acid
CAS:
182249-69-0
MF:
C30H48O5
Structure:
Chemical Name:
7-O-Acetylbonducellpin C
CAS:
197781-86-5
MF:
C25H34O8
Structure:
Chemical Name:
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
CAS:
57719-81-0
MF:
C20H28O4
Structure:
Chemical Name:
TAXININE
CAS:
3835-52-7
MF:
C35H42O9
Structure:
Chemical Name:
cauloside A
CAS:
17184-21-3
MF:
C35H56O8
Structure:
Chemical Name:
tripterifordin
CAS:
139122-81-9
MF:
C20H30O3
Structure:
Chemical Name:
paeonilactone A
CAS:
98751-79-2
MF:
C10H14O4
Structure:
Chemical Name:
jolkinolide E
CAS:
54494-34-7
MF:
C20H28O2
Structure:
Chemical Name:
galanolactone
CAS:
115753-79-2
MF:
C20H30O3
Structure:
Chemical Name:
Coronarin B
CAS:
119188-38-4
MF:
C20H30O4
Structure:
Chemical Name:
trans-Communol
CAS:
10178-31-1
MF:
C20H32O
Structure:
Chemical Name:
Methyl hydroxyangolensate
CAS:
22255-07-8
MF:
C27H34O8
Structure:
Chemical Name:
Hedragonic acid
CAS:
466-02-4
MF:
C29H44O3
Structure:
Chemical Name:
16-Hydroxy-2-oxocleroda-3,13-dien-15,16-olide
CAS:
165459-53-0
MF:
C20H28O4
Structure:
Chemical Name:
3-O-(E)-Hydroxycinnamoyl oleanolic acid
CAS:
151334-06-4
MF:
C39H54O5
Structure:
Chemical Name:
(2alpha,3beta)-2,3-Dihydroxyoleana-11,13(18)-dien-28-oic acid
CAS:
71850-15-2
MF:
C30H46O4
Structure:
Chemical Name:
ent-Labda-8(17),13Z-diene- 15,16,19-triol 19-O-glucoside
CAS:
1245636-01-4
MF:
C26H44O8