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Analytical Chemistry

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Analytical chemistry is the subject for the method and basic principle of studying and identifying of the composition, status, structure of matter as well as determination of related content. It is an important branch of chemistry subject. Analytical chemistry plays an important role in not only its own development but also in various fields related to the chemistry. We can say that all the practice of any human activity involving chemical phenomena is inseparable from analytical chemistry. Now, people have developed various kinds of different analytical methods, which can be classified based on an analysis task, analysis object, the basis of the analysis, requirement of the analysis and sample dosage.

According to the analysis tasks, it can be divided into qualitative analysis, quantitative analysis and structural analysis. Task of qualitative analysis is to identify the elements, radicals, functional groups or compounds that constituting the substances; the task of the quantitative analysis is to determine the content of the related components in the sample; the task of structural analysis is to study the molecular structure or crystal structure of the material.

(1) According to the analysis objects, it can be divided into organic and inorganic analysis; the object for the inorganic analysis is inorganic substance; the object of organic analysis is organic substance. In the inorganic analysis, it is generally required to determine what elements, ions, radicals or compounds that constitutes the sample and measure the percentage of each component; and sometimes it is also necessary for determination of the crystal structure; in the organic analysis, it not only requires the identification of the constituent elements, but also, more importantly, should do the structure analysis and functional group analysis.
(2) According to whether the analysis is based on the physical properties or chemical properties of the substance, it can be divided into instrumental analysis and chemical analysis. Depending on the specific requirements, it can be divided into routine analysis, rapid analysis and arbitration Analysis. Routine analysis refers to the general daily laboratory production analysis, also known as conventional analysis; rapid analysis is a kind of routine analysis and is mainly applied to the control of the production process, demanding the report of the results in the shortest possible time with the error generally being allowed to be greater; arbitration analysis is needed when there is controversy in the analysis results from different institute, demanding related department to conduct accurate analysis using specific method in order to determine the accuracy of the results of the original analysis.
(3) According to the amount of the sample, it can be generally divided into constant (> 0.1g), semi-micro (0.01 ~ 0.1g) and trace (1 ~ 10mg) analysis.
(4) In the inorganic qualitative chemical analysis, people generally apply semi-micro method while people generally apply constant analysis in the quantitative chemical analysis. According to the relative amounts of the analyzed components contained in the sample, it is also roughly divided into constant component analysis (> 1%), minor component analysis (0.01 to 1%) and trace components analysis (<0.01%). For the analysis of some trace amount of components contained in some kinds of complicated mixture and some substances, it is necessary to perform separation and enrichment. This produces a series of separation techniques, such as extraction, distillation, ion exchange, chromatography, sedimentation and flotation separation, these chemical separation techniques are an integral part of the analysis.

Environmental Analytical Chemistry
Environmental Analytical Chemistry is briefly referred to environmental analysis. It is a kind of subject to study the types, components of pollutants in the environment as well as how to perform qualitative and quantitative analysis on the chemical contaminants in the environment. It is a branch of environmental chemistry.

Environmental analytical chemistry emerged, developed and improved during the process of solving environmental problems. In 1950s, the public nuisance disease occurred in Japan had alerted the whole world. In order to find the cause of public nuisance disease, after experiencing as long as 11 years, later, the chemists of environmental analysis had applied light spectrum and identified that the river in Itai-itai disease area contained harmful elements such as lead, cadmium, arsenic and so on. Further by means of tracking element analysis of the soil and food in the disease area, people had found high lead and cadmium content. Later, people had further conducted spectral quantitative analysis on the body and bone of the patients in the disease area and found that the bone ashes contained alarmingly high content of zinc, lead and cadmium. To determine the causative agent, people further incorporated zinc, lead and cadmium into the food for feeding animals and conduct trace elemental analysis for animals and confirmed the serious harm of cadmium on the bone, revealing the cause of the Itai-itai disease. The development of modern science, especially the development of modern chemistry, physics, mathematics, electronics, biology, as well as the emergence of accurate, reliable, sensitive, selective, rapid, simple environmental pollution analysis technology and automation equipment, has been resulting in the maturation of environmental analytical chemistry. Environmental analytical chemistry now has penetrated into all areas of the entire environmental science subject. It is the most effective means of access to environmental information quality.
The objects of the environmental analytical chemistry research are quite complicated, including air, water, soil, sediment, minerals, waste, animals, plants, food, and human tissue. The content of chemical elements or compound to be determined in the environmental analytic chemistry is very low, with the absolute content being within the level of 10-6 to 10-12 grams.


The analysis technology in the environmental analytical chemistry is developing towards the direction of continuous automation, computerization and joint combination of various methods and instruments. Currently applied automatic analysis methods include colorimetric analysis, ion selective electrode, x-ray fluorescence spectroscopy, atomic absorption spectroscopy, polarography, gas chromatography, liquid chromatography and flow injection analysis. Laser, as the light source of analytical chemistry technique, has also been applied. Since the laser analysis has properties of high resolution, high sensitivity, long-range and short-term, the laser technology will play a pivotal role in the development of environmental analytical chemistry.

With the deepened development of environmental science, environmental analytical chemistry is often demanded for trace levels and ultra-trace-level detection and analysis, therefore, high sensitivity. Thus study of analysis methods of high sensitivity, good selectivity, rapid trace and ultra trace will become the major development direction for environmental analysis in the near future.

Qualitative Analysis of Chemistry
Qualitative analytic chemistry is the subject to identify the chemical elements and atoms groups contained in the sample. It is a branch subject of the analysis chemistry. Its purpose is to ascertain the chemical composition of the research object (specimen).
The major research content of the qualitative analytic chemistry includes:

1 the tested samples were analyzed separately. Namely take part of the sample and use exclusive reaction to detect a desire detection component.
2 systematic analysis of the samples. This means successively apply a few selective reactions for gradual separation of the ions followed by separation of each group until separating to only one substance and finally apply confirming reaction to ascertain the existence of this substance. The most famous cation system analysis method is H2S system. In recent years, due to the use of advanced equipment, qualitative analysis has also rapidly developed together with multivariate analysis and has also become an important direction for analytical chemistry.

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Structure:
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benazepril
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131064-75-0
MF:
C24H28N2O5
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uridine 5'-tetraphosphate
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10003-94-8
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C9H16N2O18P4
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Complete set of Ampicillin Impurities
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Helicianeoide B
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496066-89-8
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C32H38O20
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1-Cyclohexene-1-carboxylicacid,4-(aminomethyl)-(9CI)
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C8H13NO2
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4-PREGNEN-6-BETA-OL-3,20-DIONE
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C21H30O3
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IMidazo[1,2-a]pyridin-6-aMine, 3-chloro-
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1094463-26-9
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C7H6ClN3
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Clarithromycin Impurity H
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C38H67NO14
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6-Des(1-Methyl-2-benziMidazolyl)-6-carboxy TelMisartan
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884330-12-5
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C26H24N2O4
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ent-Aprepitant
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172822-29-6
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C23H21F7N4O3
Structure:
Chemical Name:
(4S,5S)-4-Benzyl-5-[(2S)-2-((4S)-4-isopropyl-2,5-dioxoiMidazolidin-1-yl)-3-phenylpropyl]-2-oxo-1,3-oxazolidine-3-carboxylate thiazol-5-ylMethyl Ester
CAS:
1010809-43-4
MF:
C30H32N4O6S
Structure:
Chemical Name:
ent-Tadalafil
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629652-72-8
MF:
C22H19N3O4
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Chemical Name:
N-DesaMinosulfonyl-N-cyano FaMotidine
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MF:
C9H13N7S2
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Chemical Name:
6.7-dihydrothieno[3.2.c]pyridin-4(5H)-one
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68559-60-4
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C7H7NOS
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Chemical Name:
3-O-Methylcarbidopa
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85933-19-3
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C11H16N2O4
Structure:
Chemical Name:
C-DeMethyl ClethodiM
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112301-96-9
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C16H24ClNO3S
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Chemical Name:
5-Desthiolyl-5-thioxo Cefoperazone
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711598-76-4
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C25H27N9O8S2
Structure:
Chemical Name:
Clindamycin 3-Phosphate
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28708-34-1
MF:
C18H34ClN2O8PS
Structure:
Chemical Name:
1,2-Dithiolane-3-pentanoic acid 1-oxide
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6992-30-9
MF:
C8H14O3S2
Structure:
Chemical Name:
4-(3,4-Dihydro-4,4-dimethyl-7-pentylfuro[4,3,2-de][1]benzopyran-3-yl)-2-butanone
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70474-97-4
Structure:
Chemical Name:
3'-Demethyl-12-deoxyerythromycin
CAS:
33442-56-7
MF:
C36H65NO12
Structure:
Chemical Name:
2-[4-(4-METHOXY-PHENOXY)-PHENYL]-MALONIC ACID MONO-(4-METHOXY-PHENYL) ESTER
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70175-90-5
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C25H24O7
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Chemical Name:
N-[2-[(Methylamino)carbonyl]benzoyl]
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721958-72-1
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C29H32ClN3O7
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Chemical Name:
2-AMino-3-(4-broMobenzoyl)phenyloxoacetic Acid
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1391052-54-2
MF:
C15H10BrNO4
Structure:
Chemical Name:
Micafungin FR-179642 impurity (acid)
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168110-44-9
MF:
C35H52N8O20S
Structure:
Chemical Name:
(3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile
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1640971-60-3
MF:
C14H20N6O
Structure:
Chemical Name:
AMlodipine iMpurity
MF:
C26H31ClN2O8S
Structure:
Chemical Name:
Cephalexin IMpurity C
MF:
C16H17N3O4S
Structure:
Chemical Name:
Finasteride IMpurity C
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1329611-51-9
MF:
C23H34N2O2
Structure:
Chemical Name:
(R)-AMbrisentan
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1007358-76-0
MF:
C22H22N2O4
Structure:
Chemical Name:
Ivabradine IMpurity
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1616710-50-9
MF:
C27H35ClN2O6
Structure:
Chemical Name:
1,2-Bis(piperazin-1-yl)benzene
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1446750-99-7
MF:
C14H22N4
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Chemical Name:
4-Methyl-N-(3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl)-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzaMide
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641571-15-5
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C28H22F3N7O
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Pentoxifylline Impurity I
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55247-90-0
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C14H14N4O2
Structure:
Chemical Name:
Pentoxifylline Impurity I
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C14H14N4O2
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Axitinib Impurity C
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Pregabalin EP Impurity A
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181289-23-6
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C8H15NO
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Chemical Name:
Amoxicillin EP Impurity L
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1789703-32-7
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C24H29N5O7S2
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Chemical Name:
Cefotiam Impurity 2
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1566599-01-6
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C13H12N4O4S2
Structure:
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Posaconazole Impurity 43
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357189-95-8
MF:
C37H40F2N8O6
Structure:
Chemical Name:
Tedizolid Impurity 34
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2095200-69-2
MF:
C16H18FN6O5P
Structure:
Chemical Name:
JYMSVNHODSJOPS-UHFFFAOYSA-N
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46053-56-9
MF:
C8H10N2O2
Structure:
Chemical Name:
Levosimendan Impurity 4
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131741-37-2
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C14 H14 N6 O2
Structure:
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Nicorandil Impurity 5
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C8H10N2O3
Structure:
Chemical Name:
Ampicillin EP Impurity M
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62326-82-3
MF:
C32H38N6O8S2
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Diclindamycin Pyrophosphate/Clindamycin Phosphate EP Impurity K
Chemical Name:
Dapagliflozin Impurity 27
Structure:
Chemical Name:
Celecoxib Impurity 23
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2247197-66-4
MF:
C18H15F3N2O3S
Structure:
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5-(4-Fluorophenyl)thiophene-2-carboxylic acid
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115933-30-7
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C11H7FO2S
Structure:
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Moxifloxacin Impurity 29
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C21H22FN3O5
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2H-Isoindole-2-butanoic acid, 4-amino-γ-(aminocarbonyl)-1,3-dihydro-1-oxo-
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C13H15N3O4
Structure:
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Paeoniflorgenin
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697300-41-7
MF:
C17H18O6
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Reference preparation
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Atracurium EP Impurity K
Structure:
Chemical Name:
Amoxicillin Impurity 3
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297175-66-7
MF:
C31H40N6O9S2
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Ceftizoxime sodium Impurity 6
Structure:
Chemical Name:
PROPOFOL RELATED COMPOUND C (50 MG) (2,6-DIISOPROPYLPHENYL ISOPROPYLETHER)
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141214-18-8
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C15H24O
Structure:
Chemical Name:
2-Methyltetrahydropyran
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10141-72-7
MF:
C6H12O
Structure:
Chemical Name:
Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]-
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2484719-15-3
MF:
C27H37NO
Structure:
Chemical Name:
2-((2-naphthyloxy)methyl)-oxiran
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5234-06-0
MF:
C13H12O2
Chemical Name:
6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Structure:
Chemical Name:
Acetamide, N-[2-[1-(3,4-diethoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
CAS:
2448678-64-4
MF:
C23H26N2O7S
Structure:
Chemical Name:
2-(4-(2-(4-(1-(ethoxymethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid
MF:
C27H35N3O3
Structure:
Chemical Name:
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-
CAS:
2084136-51-4
MF:
C21H20N4O3
Chemical Name:
Ritonavir EP Impurity LNO
Structure:
Chemical Name:
1,6-Naphthyridine-3-carboxamide, 4-(4-cyano-2-methoxyphenyl)-1,4-dihydro-5-methoxy-2,8-dimethyl-
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2640280-84-6
MF:
C20H20N4O3
Structure:
Chemical Name:
deoxyfructosazine
CAS:
17460-13-8
MF:
C12H20N2O7
Structure:
Chemical Name:
3-Hydroxy-4,5-dimethoxybenzoic acid
CAS:
1916-08-1
MF:
C9H10O5
Structure:
Chemical Name:
CYPERENONE
CAS:
3466-15-7
MF:
C15H22O
Chemical Name:
BOTRYTISCINEREA
CAS:
72882-27-0
Structure:
Chemical Name:
Chikusetsu saponin Ib
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59252-87-8
MF:
C47H74O18
Structure:
Chemical Name:
3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL
CAS:
73590-93-9
MF:
C8H11Cl2N
Structure:
Chemical Name:
Cetirizine Amide
CAS:
83881-37-2
MF:
C21H26ClN3O2
Structure:
Chemical Name:
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
CAS:
51333-05-2
MF:
C27H36O7
Structure:
Chemical Name:
Dihydro-FK506
CAS:
104987-30-6
MF:
C44H71NO12
Structure:
Chemical Name:
Dehydro Tizanidine
CAS:
125292-34-4
MF:
C9H6ClN5S
Structure:
Chemical Name:
α-Ribavirin (Ribavirin Impurity B)
CAS:
57198-02-4
MF:
C8H12N4O5
Structure:
Chemical Name:
1-(3-BroMopropyl)theobroMine
CAS:
6493-10-3
MF:
C10H13BrN4O2
Structure:
Chemical Name:
5-(5-Carboxy-2-ethoxyphenyl)-1-Methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyriMidin-7-one
CAS:
147676-78-6
MF:
C18H20N4O4
Structure:
Chemical Name:
FaMotidine Acid IMpurity Methyl Ester
CAS:
76824-14-1
MF:
C9H14N4O2S2
Structure:
Chemical Name:
SiMvastatin Hydroxy Acid Ethyl Ester
CAS:
864357-87-9
MF:
C27H44O6
Structure:
Chemical Name:
Atomoxetine Related Compound B (10 mg) (N-Methyl-3-phenyl-3-(m-tolyloxy)propan-1-amine hydrochloride)
CAS:
873310-28-2
MF:
C17H22ClNO
Structure:
Chemical Name:
(αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenepentanaMide
CAS:
1197811-72-5
MF:
C24H23F2NO3
Structure:
Chemical Name:
Entacapone EP IMpurity I
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1364322-42-8
MF:
C13H12N2O6
Structure:
Chemical Name:
(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide
CAS:
214398-99-9
MF:
C7H11ClN2O2
Structure:
Chemical Name:
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
CAS:
720720-96-7
MF:
C8H11ClN2O2S
Structure:
Chemical Name:
(S)-2-((6-(3-aMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)benzonitrile
CAS:
1353254-15-5
MF:
C18H25N3O2
Structure:
Chemical Name:
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-propyl ester
CAS:
1797124-83-4
MF:
C38H45N3O6
Structure:
Chemical Name:
Sildenafil EP IMpurity D
CAS:
1357931-55-5
MF:
C17H20N4O5S
Structure:
Chemical Name:
TaMsulosin EP IMpurity D
CAS:
1799280-05-9
MF:
C19H26N2O5S
Structure:
Chemical Name:
Ticagrelor Sulphone
CAS:
1788033-05-5
MF:
C23H28F2N6O4S
Structure:
Chemical Name:
3-Acetyl-17-deacetyl Rocuronium Bromide
CAS:
1190105-63-5
MF:
C32H53BrN2O4
Structure:
Chemical Name:
Empagliflozin Impurity
CAS:
2253771-11-6
MF:
C21H25ClO8
Structure:
Chemical Name:
Axitinib Impurity c
CAS:
885126-40-9
MF:
C22H18N4OS
Chemical Name:
Nicorandil Impurity
Structure:
Chemical Name:
(1S,2R,3R)-Aprepitant
CAS:
1242175-34-3
MF:
C23H21F7N4O3
Structure:
Chemical Name:
Cefoxitin Impurity 6
CAS:
1422023-32-2
MF:
C16H17N3O7S2
Structure:
Chemical Name:
Tebipenem pivoxil impurity P6
CAS:
1665289-91-7
MF:
C23H33N3O7S2
Structure:
Chemical Name:
Rivaroxaban Impurity 28
CAS:
2489689-18-9
MF:
C23H25N3O5
Structure:
Chemical Name:
Amoxicillin Impurity N
MF:
C16H19N3O5S