COLISTIN Chemical Properties

Boiling point:

807.67°C (rough estimate)

Density 

1.1050 (rough estimate)

refractive index 

1.6700 (estimate)

storage temp. 

Store at -20°C

solubility 

PBS (pH 7.2): 10 mg/ml

CAS DataBase Reference

1066-17-7

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

1066-17-7(Hazardous Substances Data)

Toxicity

cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960.

COLISTIN Usage And Synthesis

Neurotoxicity and Nephrotoxicity

Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.

Uses

Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.

brand name

Coly-Mycin (Monarch).

COLISTIN(1066-17-7)Related Product Information

• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• COLISTIN
• Cupric acetylacetonate
• Tris(2,4-pentanedionato)chroMiuM(III)
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• TERT-BUTYL ISOCYANIDE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• METHYL ISOCYANOACETATE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Benzyl isocyanide
• Ferric acetylacetonate
• COBALT(II) ACETYLACETONATE
• N-BUTYLISOCYANIDE
• PHENYLSELENOL
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• Ethyl isocyanoacetate
• Aluminum acetylacetonate
• Tosylmethyl isocyanide