Cyclicdimethylpolysiloxane Chemical Properties

EPA Substance Registry System

Cyclomethicone (69430-24-6)

Safety Information

RIDADR 

1993

HazardClass 

3.2

PackingGroup 

III

Hazardous Substances Data

69430-24-6(Hazardous Substances Data)

Cyclicdimethylpolysiloxane Usage And Synthesis

Chemical Properties

Cyclomethicone occurs as a clear, colorless and tasteless volatile liquid.

Uses

Pharmaceutic aid (wetting agent).

Production Methods

Cyclomethicone is manufactured by the distillation of crude polydimethylsiloxanes.

brand name

VS-7158 (Witco); VS-7207 (Witco); VS-7349 (Witco).

Pharmaceutical Applications

Cyclomethicone is mainly used in topical pharmaceutical and cosmetic formulations such as water-in-oil creams.
Cyclomethicone has been used in cosmetic formulations, at concentrations of 0.1-50%, since the late 1970s and is now the most widely used silicone in the cosmetics industry. Its high volatility, and mild solvent properties, make it ideal for use in topical formulations because its low heat of vaporization means that when applied to skin it has a ‘dry’ feel.

Safety

Cyclomethicone is generally regarded as a relatively nontoxic and nonirritant material. Although it has been used in oral pharmaceutical applications, cyclomethicone is mainly used in topical pharmaceutical formulations. It is also widely used in cosmetics. Studies of the animal and human toxicology of cyclomethicone suggest that it is nonirritant and not absorbed through the skin. Only small amounts are absorbed orally; an acute oral dose in rats produced no deaths.

storage

Cyclomethicone should be stored in an airtight container in a cool, dry, place.

Regulatory Status

Included in the FDA Inactive Ingredients Database(oral powderfor reconstitution, topical lotion, topical cream, topical emulsion). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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