Basic information Safety Supplier Related

Pomalidomide-O-C4-NH2

Basic information Safety Supplier Related

Pomalidomide-O-C4-NH2 Basic information

Product Name:
Pomalidomide-O-C4-NH2
Synonyms:
  • 1H-Isoindole-1,3(2H)-dione, 4-(4-aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-
  • Thalidomide-4-O-C4-NH2
  • 4-(4-Aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • 4-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:
1957235-96-9
MF:
C17H19N3O5
MW:
345.35
Mol File:
1957235-96-9.mol
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Pomalidomide-O-C4-NH2 Chemical Properties

Boiling point:
620.4±55.0 °C(Predicted)
Density 
1.387±0.06 g/cm3(Predicted)
pka
10.70±0.40(Predicted)
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Pomalidomide-O-C4-NH2 Usage And Synthesis

Uses

Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Pomalidomide-O-C4-NH2Supplier

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ShenZhen Trendseen Biological Technology Co.,Ltd.
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Pomalidomide-O-C4-NH2(1957235-96-9)Related Product Information