Basic information Safety Supplier Related

TREHALOSE 6,6'-DIMYCOLATE

Basic information Safety Supplier Related

TREHALOSE 6,6'-DIMYCOLATE Basic information

Product Name:
TREHALOSE 6,6'-DIMYCOLATE
Synonyms:
  • TREHALOSE 6,6'-DIMYCOLATE
  • CORD FACTOR
  • TREHALOSE 6,6'-DIMYCOLATE FROM*MYCOBACTE RIUM TUBERC
  • 6,6'-di-o-mycoloyl-α,α-trehalose
  • trehalose 6,6'-dimycolate from mycobacterium tuberculosis
  • 6,6μ-Di-O-mycoloyl-α,α-trehalose, Cord factor
  • 6,6'-DI-O-MYCOLOYL-ALPHA,ALPHA-TREHALOSE
  • Trehalose 6,6′-diMycolate froM MycobacteriuM bovis
CAS:
61512-20-7
MF:
C130H250O15.C2H6
MW:
0
Mol File:
Mol File
More
Less

TREHALOSE 6,6'-DIMYCOLATE Chemical Properties

storage temp. 
−20°C
form 
Powder
color 
White to off-white
More
Less

Safety Information

WGK Germany 
3

MSDS

More
Less

TREHALOSE 6,6'-DIMYCOLATE Usage And Synthesis

Uses

Trehalose 6,6'-dimycolate (Cord Factor) is trehalose 6,6'-dimycolate, a cell wall glycolipid of Mycobacterium tuberculosis, which can be used to simulate inflammation and granuloma induced by Mycobacterium tuberculosis (MTB) form. Trehalose 6,6′-dimycolate also protects Mycobacterium tuberculosis from macrophage-mediated killing, inhibits efficient antigen presentation, and reduces the development of protective T cell responses[1][2].

in vivo

1. Induce inflammation and granuloma formation[1]
Pathogenic mechanism
Trehalose 6,6’-dimycolate prevents calcium-mediated fusion of phagosomes and lysosomes, inhibits phagolysosome acidification, and thereby inhibits the killing effect of mouse macrophages on Mycobacterium tuberculosis, impairs the body's effective immune response, and induces the expression of matrix metalloproteinases.
Specific modeling method
Mice: C57BL/6 ? female ? 6-8 week-old (period: 7 days)
Administration: 0.5 or 1.25 mg/kg ? i.v., or i.p. first then i.v. ? once
Modeling success index
Phenotypic observation ：Macrophages gather locally, the size and number of granulomas increase, inflammation intensifies, alveolar spaces decrease, there are small hemorrhages, and lymphocytes mainly infiltrate at the junction of granulomas and blood vessels.
Animal Model:Female C57BL/6 mice (6-8 weeks, 20 g)[1]
Dosage:0.5, 1.25 mg/kg (10 μg, 25 μg per 20 g mice)
Administration:Intravenous injection (i.v.) once (0.5, 1.25 mg/kg), or received 0.5 mg/kg via Intraperitoneal injection (i.p.) followed by an i.v. after 7 days of 0.5 mg/kg
Result:Increased the lung weight index (LWI). Local aggregation of macrophages was observed 7 days later at 0.5 mg/kg. The size and number of granulomas increased, inflammation intensified, alveolar spaces decreased, small hemorrhagic petechiae appeared, and lymphocytes mainly infiltrated at the intersection of granulomas and blood vessels at 1.25 mg/kg. In i.p.+i.v. model, the inflammatory response was more aggressive. Induced vascular remodeling and collagen deposition.

References

[1] Hwang SA, et al. Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation. Tuberculosis (Edinb). 2019 May;116S:S118-S122. DOI:10.1016/j.tube.2019.04.019
[2] Welsh KJ, et al. Trehalose 6,6'-dimycolate--a coat to regulate tuberculosis immunopathogenesis. Tuberculosis (Edinb). 2013 Dec;93 Suppl:S3-9. DOI:10.1016/S1472-9792(13)70003-9

TREHALOSE 6,6'-DIMYCOLATESupplier

Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Email
3007715519@qq.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Email
cdhxsj@163.com
More
Less

TREHALOSE 6,6'-DIMYCOLATE(61512-20-7)Related Product Information