RYNTR Chemical Properties

storage temp. 

2-8°C

solubility 

aqueous buffer, pH 7.0: soluble

form 

buffered aqueous glycerol solution

color 

Colorless to light yellow

biological source

r at liver

Water Solubility 

water: soluble

Specific Activity

≥5units/mg protein

Safety Information

Safety Statements 

23-24/25

WGK Germany 

1

Storage Class

12 - Non Combustible Liquids

MSDS

• Language:English Provider:SigmaAldrich

RYNTR Usage And Synthesis

Uses

Thioredoxin Reductase from rat liver can be used for studying the uptake and reduction of a-lipoic acid by utilizing reducing capacity of human erythrocytes. The product can also be used for studying the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix by using Thioredoxin.

Biochem/physiol Actions

Thioredoxin reductase (TrxR) is a NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidized thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides, and hydrogen peroxide.

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