ALPHA2-MACROGLOBULIN Chemical Properties

storage temp. 

−20°C

solubility 

H₂O: 5 mg/mL, clear to faintly turbid, colorless to faintly yellow

form 

lyophilized powder

Safety Information

Hazard Codes 

B

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

HS Code 

3504009000

MSDS

• Language:English Provider:SigmaAldrich

ALPHA2-MACROGLOBULIN Usage And Synthesis

Uses

α₂-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.

Biochem/physiol Actions

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.

ALPHA2-MACROGLOBULIN(95568-41-5)Related Product Information

• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• TERT-BUTYL ISOCYANIDE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• Tosylmethyl isocyanide
• Aluminum acetylacetonate
• Ethyl isocyanoacetate
• Benzyl isocyanide
• METHYL ISOCYANOACETATE
• COBALT(II) ACETYLACETONATE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Ferric acetylacetonate
• N-BUTYLISOCYANIDE
• PHENYLSELENOL
• SALCOMINE
• Tris(2,4-pentanedionato)chroMiuM(III)
• Cupric acetylacetonate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)