Tos-PEG5-CH2CO2H
Tos-PEG5-CH2CO2H Basic information
- Product Name:
- Tos-PEG5-CH2CO2H
- Synonyms:
-
- Tos-PEG5-CH2CO2H
- Tos-PEG4-CH2COOH
- Acetic acid, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
- Tos-PEG5-CH2COOH
- 14-(Tosyloxy)-3,6,9,12-tetraoxatetradecanoic acid
- 14-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12-tetraoxatetradecanoic acid
- 14-(Tosyloxy)-3,6,9,12-tetraoxatetradecan-1-oic Acid
- CAS:
- 2028284-73-1
- MF:
- C17H26O9S
- MW:
- 406.45
- Mol File:
- 2028284-73-1.mol
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Tos-PEG5-CH2CO2H Chemical Properties
- Boiling point:
- 567.7±50.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- pka
- 3.39±0.10(Predicted)
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Tos-PEG5-CH2CO2H Usage And Synthesis
Description
Tos-PEG5-CH2CO2H is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
Tos-PEG5-CH2CO2HSupplier
Jinan elephant international trading co., LTD
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- 13006575422@163.com
Shanghai Yihe Biological Technology Co., Ltd.
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- 021-68882955 17721395025
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TargetMol Chemicals Inc.
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- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
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- 13892832556
- 2440688701@qq.com
Zhengzhou Convergence Chemical Co. LTD
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- 0371-0371-53736046 13393710386
- 2853979814@qq.com