Tos-PEG4-acid Chemical Properties

Boiling point:

548.3±50.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

pka

4.27±0.10(Predicted)

color 

Colorless to light yellow

Tos-PEG4-acid Usage And Synthesis

Description

Tos-PEG4-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6

Tos-PEG4-acid(1453117-42-4)Related Product Information

• Tos-PEG5 t-butyl ester
• Tos-PEG2-CH2CO2tBu
• Tos-PEG2-t-butyl ester
• Tos-PEG4-CH2CO2H
• Tos-PEG4-t-butyl ester
• Tos-PEG6-t-Butyl ester
• Tos-PEG3-CH2CO2tBu
• Tos-PEG5-CH2CO2H
• Tos-PEG5-CH2CO2t-butyl ester
• Tos-PEG3-CH2CO2H