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N-Boc-L-tert-Leucine

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N-Boc-L-tert-Leucine Basic information

Product Name:
N-Boc-L-tert-Leucine
Synonyms:
  • BOC-TBU-GLYCINE
  • BOC-TBU-GLY-OH
  • BOC-TLE
  • BOC-TLE-OH
  • BOC-ALPHA-BUTYLGLYCINE
  • BOC-ALPHA-T-BUTYLGLYCINE
  • BOC-ALPHA-T-BUTYLGLYCINE-OH
  • BOC-ALPHA-T-BUTYL-GLY-OH
CAS:
62965-35-9
MF:
C11H21NO4
MW:
231.29
EINECS:
613-118-8
Product Categories:
  • Leucine [Leu, L]
  • Amino Acids
  • Amino Acids & Deriv.
  • CHIRAL CHEMICALS
  • Peptide
Mol File:
62965-35-9.mol
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N-Boc-L-tert-Leucine Chemical Properties

Melting point:
118-121 °C
alpha 
-4.2 º (c=1% in glacial acetic acid)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Crystalline Powder
color 
White to slightly yellow
optical activity
[α]20/D 4.2±0.5°, c = 1% in glacial acetic acid
BRN 
1962763
InChI
InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3
InChIKey
LRFZIPCTFBPFLX-SSDOTTSWSA-N
SMILES
[C@@H](C(=O)O)(C(C)(C)C)NC(=O)OC(C)(C)C |&1:0,r|
CAS DataBase Reference
62965-35-9(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
2924 19 00
HazardClass 
IRRITANT

MSDS

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N-Boc-L-tert-Leucine Usage And Synthesis

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical Properties

White crystalline powder

Uses

Atazanavir Related Compound A

N-Boc-L-tert-LeucineSupplier

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