N-Boc-L-tert-Leucine Chemical Properties

Melting point:

118-121 °C

alpha 

-4.2 º (c=1% in glacial acetic acid)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Crystalline Powder

color 

White to slightly yellow

optical activity

[α]20/D 4.2±0.5°, c = 1% in glacial acetic acid

BRN 

1962763

InChI

InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3

InChIKey

LRFZIPCTFBPFLX-SSDOTTSWSA-N

SMILES

[C@@H](C(=O)O)(C(C)(C)C)NC(=O)OC(C)(C)C |&1:0,r|

CAS DataBase Reference

62965-35-9(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

2924 19 00

HazardClass 

IRRITANT

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

N-Boc-L-tert-Leucine Usage And Synthesis

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical Properties

White crystalline powder

Uses

Atazanavir Related Compound A

N-Boc-L-tert-Leucine(62965-35-9)Related Product Information

• 3-Aminophenol
• tert-Butanol
• ALTRENOGEST
• N-Carbobenzyloxyglycine
• L-tert-Leucine
• 6-Aminocaproic acid
• Glycine
• N-CARBOBENZOXY-DL-LEUCINE
• Tris(hydroxymethyl)aminomethane
• N-Boc-L-Phenylalaninol
• BOC-L-Prolinol
• N-Boc-L-alaninol
• BOC-L-NORLEUCINE
• Methoxycarbonyl-L-tert-leucine
• BOC-D-TERT-LEUCINE,N-BOC-D-TERT-LEUCINE
• (2S,4R)-N-Boc-4-hydroxy-3,3-dimethylpyrrolidine-2-carboxylic acid
• (S)-N-Boc-3,3-dimethylpyrrolidine-2-carboxylic acid
• (S)-Boc-1-adamantyl-glycine