Deoxyarbutin Chemical Properties

Melting point:

88-89 °C(Solv: ligroine (8032-32-4))

Boiling point:

349.8±32.0 °C(Predicted)

Density 

1.174

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)

pka

10.10±0.15(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

Safety Information

HS Code 

2932990090

Deoxyarbutin Usage And Synthesis

Description

Deoxyarbutin is a tyrosinase inhibitor (IC₅₀ = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC₅₀ = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.

Uses

Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.

Preparation

Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.

Deoxyarbutin(53936-56-4)Related Product Information

• 3-O-Ethyl-L-ascorbic acid
• Laurocapram
• Wogonin
• ARTEMISININ
• Arbutin
• Arbutin
• Azelaic acid
• Trimethylglycine
• Sodium deoxycholate
• Ellagic acid
• 1-Deoxynojirimycin
• Sodium ascorbate
• Hydroxytyrosol
• Chebulinic acid
• 10-Gingerol
• 3,4-Dimethoxybenzyl alcohol
• Levocetirizine dihydrochloride
• Kojic acid