Ald-PEG5-t-butyl ester CAS#: 1446282-23-0

Ald-PEG5-t-butyl ester Basic information

Product Name:

Ald-PEG5-t-butyl ester

Synonyms:

Ald-PEG5-t-butyl ester
Ald-CH2-PEG5-CH2CH2COOtBu
ALD-CH2-PEG5-T-BUTYL ESTER
CHOCH2-PEG5-COOtBu
CHO-PEG5-COOtBu
Ald-CH2-PEG5-Boc
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-oxo-, 1,1-dimethylethyl ester
tert-butyl 1-oxo-3,6,9,12,15-pentaoxaoctadecan-18-oate

CAS:

1446282-23-0

MF:

C17H32O8

MW:

364.43

Product Categories:

peg

Mol File:

1446282-23-0.mol

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Ald-PEG5-t-butyl ester Usage And Synthesis

Description

Ald-CH2-PEG5-t-butyl ester is an aldehyde PEG linker that is reactive with aminooxy-containing molecules. The t-butyl ester can be removed under acidic conditions for further conjugation.PEG5 spacer of the compound arimproves aqueous solubility.

Uses

Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505

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