Cyclopropanecarboxaldehyde Chemical Properties

Boiling point:

98-101 °C (lit.)

Density 

0.938 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.4298(lit.)

Flash point:

45 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform

form 

clear liquid

color 

Colorless to Light orange to Yellow

Water Solubility 

Soluble in water.

Sensitive 

Air Sensitive

BRN 

906781

Stability:

Volatile

InChIKey

JMYVMOUINOAAPA-UHFFFAOYSA-N

CAS DataBase Reference

1489-69-6(CAS DataBase Reference)

NIST Chemistry Reference

Cyclopropanecarboxaldehyde(1489-69-6)

EPA Substance Registry System

Cyclopropanecarboxaldehyde (1489-69-6)

Safety Information

Hazard Codes 

F,C

Risk Statements 

11-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2924 3/PG 2

WGK Germany 

3

RTECS 

GZ1005000

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29122990

MSDS

• Language:English Provider:Cyclopropanecarboxaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Cyclopropanecarboxaldehyde Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Cyclopropanecarboxaldehyde reacts with Grignard or organolithium reagents to give the expected secondary alcohols. These are susceptible to ring opening in the presence of HBr, providing stereoselective access to homoallylic bromides. It is also used in the synthesis of eta(2)-enonenickel complexes by reacting with [Ni(cod)(2)] (cod = 1,5-cyclooctadiene) and PBu(3) and to prepare a cyclopropylidene tetralone which underwent an enantioselective palladium-catalyzed [3+2] TMM cycloaddition providing a chiral spiro-fused cyclopentene.

Application

Cyclopropanecarboxaldehyde is a reagent in the preparation of N-alkylphenylalaninamides of pyridinylphenyland oxobipyridinylamines as human GPR 142 agonists for potential use as anti-diabetic agents and the cytochrome P 450 inhibition.

Preparation

Cyclopropanecarboxaldehyde is prepared by reaction of cyclopropylmethanol. The reaction needs reagent pyridinium chlorochromate and solvent CH2Cl2 with other condition of ambient temperature for 3 hours. The yield is about 60%.

Definition

ChEBI: Cyclopropanecarbaldehyde is an organooxygen compound.

Cyclopropanecarboxaldehyde(1489-69-6)Related Product Information

• Cyclopropanecarboxylic acid
• Cyromazine
• Propiconazole
• Ciprofloxacin hydrochloride
• Ciprofloxacin
• Ciprofloxacin lactate
• Formaldehyde
• Methyl cyclopropane carboxylate
• (Bromomethyl)cyclopropane
• Butyl Cyclopropanesulfonate
• CYCLOPROPANESULFINIC ACID, SODIUM SALT
• Cyclopropanesulfonyl chloride
• CYCLOPROPANECARBOXYLIC ACID HYDRAZIDE
• tert-butyl cyclopropanecarboxylate
• 2-METHYLCYCLOPROPANECARBOXYLIC ACID
• 4-Chlorophenyl cyclopropyl ketone
• 1-(4-CHLOROPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID
• Cyclopropyl phenyl ketone