DBCO-PEG4-DBCO Chemical Properties

Boiling point:

1104.6±65.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture

form 

Solid

pka

14.84±0.46(Predicted)

color 

White to yellow

DBCO-PEG4-DBCO Usage And Synthesis

Description

DBCO-PEG4-DBCO is a homobifunctional PEG linker containing two DBCO groups and a hydrophilic PEG spacer arm. DBCO will react with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. The hydrophilic PEG spacer arm can increase water solubility and membrane permability.

Uses

DBCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. DBCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Cleavable Linker; PEGs

References

[1] Adam TIBBLES, et al. Engineered O-glycosylation in recombinant polypeptides via heterologous glycosylation sites. WO2019122234A1.

DBCO-PEG4-DBCO(2182601-68-7)Related Product Information

• DBCO-PEG4-Acid
• DBCO-PEG4-biotin
• DBCO-PEG4-Benzylamine
• DBCO-PEG4-Val-Cit-PAB-PNP
• DBCO-PEG4-maleimide
• DBCO-PEG4-SE
• DBCO-PEG4-amine
• Polyethylene Glycol
• DBCO-PEG1-amine
• 5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester
• DBCO-PEG3-CH2CO-NHS
• DBCO-NHS Ester
• DBCO-PEG2-NH-Boc
• Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester
• DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS
• DBCO-PEG3-acid
• Azadibenzocyclooctyne-Biotin conjugate
• 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester