DBCO-PEG2-NH-Boc Chemical Properties

Boiling point:

802.8±65.0 °C(Predicted)

Density 

1.22±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

12.23±0.46(Predicted)

DBCO-PEG2-NH-Boc Usage And Synthesis

Description

DBCO-PEG2-NH-Boc is a PEG linker with a DBCO group and a Boc-protected amine. The DBCO can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions to further react.

Uses

DBCO-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG2-NH-Boc(2377004-08-3)Related Product Information

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