DBCO-PEG4-SE Chemical Properties

Density 

1.33±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

pka

15.14±0.46(Predicted)

form 

gel or oil

color 

Colourless to yellow

InChI

InChI=1S/C34H39N3O10/c38-30(11-12-31(39)36-25-28-7-2-1-5-26(28)9-10-27-6-3-4-8-29(27)36)35-16-18-44-20-22-46-24-23-45-21-19-43-17-15-34(42)47-37-32(40)13-14-33(37)41/h1-8H,11-25H2,(H,35,38)

InChIKey

RRCXYKNJTKJNTD-UHFFFAOYSA-N

SMILES

C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCC(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)=O

Safety Information

WGK Germany 

3

HS Code 

2942000090

DBCO-PEG4-SE Usage And Synthesis

Description

DBCO-PEG4-NHS Ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Succinimidyl ester (NHS, amine reactive) functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free click chemistry cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

• Protein-peptide conjugates
• Antibody-enzyme or antibody-drug conjugates
• Protein or peptide-oligonucleotide conjugates
• Surface modification

DBCO-PEG4-SE(1427004-19-0)Related Product Information

• Diazo Biotin-PEG3-DBCO
• PC DBCO-PEG3-Biotin
• Desthiobiotin-PEG4-DBCO
• 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
• DBCO-amine
• DBCO-NHS Ester
• DBCO-sulfo-NHS ester
• DBCO-C6-NHS ester
• DBCO-PEG4-Acid
• DBCO-PEG4-biotin
• DBCO-PEG4-Benzylamine
• DBCO-PEG4-Val-Cit-PAB-PNP
• DBCO-PEG4-maleimide
• DBCO-PEG4-DBCO
• DBCO-PEG4-amine
• DBCO-SE
• DBCO-PEG5-NHS ester