4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties

Melting point:

72-73 °C

Boiling point:

177-180 °C(Press: 4.5 Torr)

Density 

1.102±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL at warmed (clear solution)

form 

powder

pka

7.34±0.61(Predicted)

color 

white to beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

4-Methyl-2-(1-piperidinyl)-quinoline Usage And Synthesis

Description

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

Uses

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

storage

Store at +4°C

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