4-Methyl-2-(1-piperidinyl)-quinoline
4-Methyl-2-(1-piperidinyl)-quinoline Basic information
- Product Name:
- 4-Methyl-2-(1-piperidinyl)-quinoline
- Synonyms:
-
- 4-Methyl-2-(1-piperidinyl)-quinoline
- ML 204
- NSC 25850
- ML-204;ML204
- 4-methyl-2-(piperidin-1-yl)quinoline
- Quinoline, 4-methyl-2-(1-piperidinyl)-
- Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
- ML 204, TRPC4 blocker
- CAS:
- 5465-86-1
- MF:
- C15H18N2
- MW:
- 226.32
- Product Categories:
-
- Inhibitors
- Aromatics, Heterocycles, Inhibitors
- Mol File:
- 5465-86-1.mol
4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties
- Melting point:
- 72-73 °C
- Boiling point:
- 177-180 °C(Press: 4.5 Torr)
- Density
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL at warmed (clear solution)
- form
- powder
- pka
- 7.34±0.61(Predicted)
- color
- white to beige
4-Methyl-2-(1-piperidinyl)-quinoline Usage And Synthesis
Description
ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.
Uses
4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.
Biochem/physiol Actions
ML204 is a potent and selective TRPC4 channel inhibitor.
in vivo
ML204 (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice[4].
| Animal Model: | Nonfasted male C57BL/6 (2-3 months)[4] |
| Dosage: | 1?mg/kg |
| Administration: | Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) |
| Result: | Induced mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response. |
IC 50
TRPC4; TRPC5
storage
Store at +4°C
References
[1] ERIKO MICHISHITA. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin[J]. Nature, 2008, 452 7186: 492-496. DOI: 10.1038/nature06736
4-Methyl-2-(1-piperidinyl)-quinolineSupplier
- Tel
- sales@boylechem.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 021-58950125
- info@chemexpress.com
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Tel
- 021-33632979
- info@tsbiochem.com
4-Methyl-2-(1-piperidinyl)-quinoline(5465-86-1)Related Product Information
- 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
- ML-228
- ML188 (Racemate)
- ML 18
- ML-098
- ML277
- ML 204
- ML329
- ML364
- VU0456810
- ML188
- ML418
- [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone
- ML213
- N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- ML-327
- PTP1B-IN-2
- ML264