4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester Chemical Properties

Density 

1.35±0.1 g/cm3(Predicted)

pka

15.14±0.46(Predicted)

form 

Solid-Liquid Mixture

color 

Off-white to light yellow

4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester Usage And Synthesis

Uses

DBCO-PEG3-NHS ester (cpmpd 45) is a ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Shih-Hsien Chuang, et al. Antibody-drug conjugates containing an anti-mesothelin antibody and uses thereof. Patent. WO2021248048.

4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester(2163772-16-3)Related Product Information

• DBCO-PEG3-OTs
• DBCO-PEG3-Val-Cit-PAB-PNP
• DBCO-PEG3-amine
• DBCO-PEG3-Gly
• DBCO-PEG3-Mal
• DBCO-PEG3-OH
• DBCO-PEG3-F
• DBCO-PEG4-triethoxysilane
• Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
• 4,7,10,13,16,19,22,25-Octaoxa-28-azadotricosanoic acid, 32-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-29,32-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-C6-acid
• DBCO-PEG2-amine
• DBCO-PEG4-maleimide
• DBCO-Acid
• DBCO-PEG1
• DBCO-PEG4-biotin
• DBCO-NHCO-PEG2-Biotin
• Ambient temperature