Ambient temperature Chemical Properties

Boiling point:

785.8±60.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO

pka

14.36±0.10(Predicted)

Ambient temperature Usage And Synthesis

Description

DBCO-PEG4-alcohol is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-alcohol is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Definition

The temperature of the environment in which an experiment is conducted or in which any physical or chemical event occurs.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Ambient temperature(1416711-60-8)Related Product Information

• DBCO-mPEG2000
• DBCO-mPEG5000
• DBCO-PEG4-triethoxysilane
• Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-PEG3-OH
• 4,7,10,13,16,19,22,25-Octaoxa-28-azadotricosanoic acid, 32-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-29,32-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-C6-acid
• DBCO-PEG2-amine
• DBCO-PEG4-maleimide
• DBCO-PEG3-Mal
• 4,7,10-Trioxa-13-azaheptadecanoic acid, 17-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-14,17-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
• DBCO-Acid
• DBCO-PEG1
• DBCO-PEG4-biotin
• DBCO-NHCO-PEG2-Biotin
• 1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-
• DBCO-PEG4-Acid
• N-(6-aminocaproyl)azadibenzocyclooctyne