DBCO-PEG2-amine Chemical Properties

Boiling point:

748.9±60.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

15.14±0.46(Predicted)

InChI

InChI=1S/C25H29N3O4/c26-13-15-31-17-18-32-16-14-27-24(29)11-12-25(30)28-19-22-7-2-1-5-20(22)9-10-21-6-3-4-8-23(21)28/h1-8H,11-19,26H2,(H,27,29)

InChIKey

ILEXOUGGKQHBOX-UHFFFAOYSA-N

SMILES

C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)NCCOCCOCCN

DBCO-PEG2-amine Usage And Synthesis

Description

DBCO-PEG2-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound.

Uses

DBCO-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG2-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG2-amine(2250216-96-5)Related Product Information

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