DBCO-PEG4-triethoxysilane Chemical Properties

Boiling point:

900.0±65.0 °C(Predicted)

Density 

1.18±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

15.14±0.46(Predicted)

form 

Liquid

color 

Colorless to light yellow

DBCO-PEG4-triethoxysilane Usage And Synthesis

Description

DBCO-PEG4-triethoxysilane is a PEG linker containing a triethoxysilane moiety and a DBCO group. Triethoxysilane is commonly used for surface modifications. DBCO group can react with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. The hydrophilic PEG chain increasse the water solubility of a compound in aqueous media.

Uses

DBCO-PEG4-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-triethoxysilane is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG4-triethoxysilane(2353410-02-1)Related Product Information

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• DBCO-Acid
• DBCO-PEG1
• DBCO-PEG4-biotin
• DBCO-NHCO-PEG2-Biotin
• Ambient temperature
• 1H-Pyrrole-1-propanamide, N-[2-[2-[3-[[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo-
• DBCO-PEG4-Acid
• N-(6-aminocaproyl)azadibenzocyclooctyne