LEPTIN, MOUSE Chemical Properties

storage temp. 

−20°C

form 

lyophilized powder

biological source

mouse

InChIKey

NRYBAZVQPHGZNS-ZSOCWYAHSA-N

Safety Information

WGK Germany 

3

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

LEPTIN, MOUSE Usage And Synthesis

Uses

Leptin from mouse has been used:

• to check the effect of leptin on ovulation for treating infertility in obese mice
• to check the effect of leptin on MGARP (mitochondria-localized glutamic acid-rich protein) expression in testis and follicular granular cells of mice
• to study the morphometrical changes in mouse testicular tissue upon long term exposure to leptin

Biochem/physiol Actions

Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.Human and mouse leptin share ~84% sequence identity.

Description

Leptin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16 kDa. The Leptin is purified by proprietary chromatographic techniques. 

Source

Escherichia Coli

Background

A 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.

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