Basic information Safety Supplier Related

m-PEG10-amine

Basic information Safety Supplier Related

m-PEG10-amine Basic information

Product Name:
m-PEG10-amine
Synonyms:
  • m-PEG10-amine
  • 3,6,9,12,15,18,21,24,27,30-Decaoxahentriacontan-1-amine
  • mPEG10-NH2/3,6,9,12,15,18,21,24,27,30-Decaoxahentriacontan-1-amine
  • 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-amine
CAS:
1383658-09-0
MF:
C21H45NO10
MW:
471.58
Product Categories:
  • peg
Mol File:
1383658-09-0.mol
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m-PEG10-amine Chemical Properties

Boiling point:
518.9±45.0 °C(Predicted)
Density 
1.065±0.06 g/cm3(Predicted)
pka
8.74±0.10(Predicted)
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m-PEG10-amine Usage And Synthesis

Description

m-PEG10-amine is reactive with activated NHS esters to form stable aminde bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

m-PEG10-amine is a non-cleavable ADC linker containing 10 units of PEG, which can be used for the synthesis of antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Non-cleavable

m-PEG10-amineSupplier

T&W GROUP
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Nanjing Norris-Pharm Technology Co., Ltd
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Nanjing Anyan Pharmaceutical Technology Co. , Ltd.
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025-58361178 17351780683
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Hunan HuaTeng Pharmaceutical Co., Ltd.,
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 18112977050
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cb6@aikonchem.com
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m-PEG10-amine(1383658-09-0)Related Product Information